Chlorinated Solvents: Their Advantages, Disadvantages, and Alternatives in Organic and Medicinal Chemistry

Jordan, Andrew; Stoy, Patrick; Sneddon, Helen F.

Abstract

Chlorinated solvents were once, and in many places are still, ubiquitous in chemistry laboratories. This review explores the properties that led to such widespread use, why there is now an increasing drive to minimize usage, and what alternatives are currently available.

Citation

Jordan, A., Stoy, P., & Sneddon, H. F. (2021). Chlorinated Solvents: Their Advantages, Disadvantages, and Alternatives in Organic and Medicinal Chemistry. Chemical Reviews, 121(3), 1582-1622. https://doi.org/10.1021/acs.chemrev.0c00709

• Journal Article Type: Review
• Acceptance Date: Dec 9, 2020
• Online Publication Date: Dec 22, 2020
• Publication Date: Feb 10, 2021
• Deposit Date: Jun 28, 2021
• Publicly Available Date: Dec 23, 2021
• Journal: Chemical Reviews
• Print ISSN: 0009-2665
• Electronic ISSN: 1520-6890
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 121
• Issue: 3
• Pages: 1582-1622
• DOI: https://doi.org/10.1021/acs.chemrev.0c00709
• Keywords: General Chemistry
• Public URL: https://nottingham-repository.worktribe.com/output/5173445
• Publisher URL: https://pubs.acs.org/doi/10.1021/acs.chemrev.0c00709
• Additional Information: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Chemical Reviews, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.chemrev.0c00709.