Two measures of systemic inflammation are positively associated with haemoglobin levels in adolescent girls living in rural India: a cross-sectional study

Ahankari, A.S.; Kabra, P.; Tata, L.J.; Hayter, M.; Fogarty, A.W.

Abstract

Objective: This study tested the hypothesis that systemic inflammation is inversely associated with haemoglobin levels in adolescent girls in India. Methods: The study population consisted of adolescent girls aged between 10 and 19years living in a remote rural region in Maharashtra State, India. Data were collected on anthropometric measures, and a venous blood sample was taken and tested for complete blood count and C-reactive protein (CRP). Results: Of 679 individuals who were invited to the research site to participate, data were available from 401 participants giving a response rate of 59%. Median blood CRP was 1.26mg/l (Range 0.00 to 26.33), and 167 (41.6%) participants had CRP level<1.0mg/l. The mean haemoglobin was 12.24g/dl (standard deviation [SD] 1.51), and the mean total white blood cells (WBC) count was 9.02×103/μl (SD 2.00). With each g/dl increase in blood haemoglobin, the risk of having an elevated CRP of≥1mg/l increased with an odds ratio of 1.16 (95% CI 1.01 to 1.33, P=0.03). Total WBC count was also positively associated with blood haemoglobin, increasing by 0.24×103/μl (95% CI 0.11 to 0.37, P<0.001) per g/dl increase in haemoglobin. Both analyses were adjusted for age. Conclusions: In this population, blood haemoglobin levels were positively associated with two measures of systemic inflammation, contrary to the primary hypothesis being tested. Other unmeasured environmental exposures may modify haemoglobin levels in this population. Understanding this observation may help design better public health interventions to improve the well-being of adolescent girls in India.

Citation

Ahankari, A., Kabra, P., Tata, L., Hayter, M., & Fogarty, A. (2021). Two measures of systemic inflammation are positively associated with haemoglobin levels in adolescent girls living in rural India: a cross-sectional study. Tropical Medicine and International Health, 26(3), 327-334. https://doi.org/10.1111/tmi.13524

• Journal Article Type: Article
• Acceptance Date: Nov 9, 2020
• Online Publication Date: Nov 9, 2020
• Publication Date: 2021-03
• Deposit Date: Nov 16, 2020
• Publicly Available Date: Nov 10, 2021
• Journal: Tropical Medicine & International Health
• Print ISSN: 1360-2276
• Electronic ISSN: 1365-3156
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 26
• Issue: 3
• Pages: 327-334
• DOI: https://doi.org/10.1111/tmi.13524
• Keywords: Public Health, Environmental and Occupational Health; Parasitology; Infectious Diseases
• Public URL: https://nottingham-repository.worktribe.com/output/5047892
• Publisher URL: https://onlinelibrary.wiley.com/doi/10.1111/tmi.13524
• Additional Information: This is the peer reviewed version of the following article: Ahankari, A., Kabra, P., Tata, L., Hayter, M. and Fogarty, A. (2020), Two measures of systemic inflammation are positively associated with haemoglobin levels in adolescent girls living in rural India: A cross‐sectional study. Trop Med Int Health., which has been published in final form at https://doi.org/10.1111/tmi.13524. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.