Effect of haemodialysis on the brain and heart assessed using multiparametric MRI

Cox, Eleanor F; Gullapudi, Venkata Rukmini Latha; Buchanan, Charlotte E; White, Kelly; Nicholas, Rosemary; Canaud, Bernard; Taal, Maarten W; Selby, Nicholas M; Francis, Susan T

Abstract

Background and hypothesis
Haemodialysis (HD) patients often develop cognitive impairment, negatively impacting health-related quality of life. We use brain magnetic resonance imaging (MRI) measures to study the acute changes in cerebral water content during HD, alongside chronic changes in HD patients compared to healthy volunteers (HV) to assess whether the brain changes associated with ageing develop more rapidly in HD patients (“accelerated brain ageing”). We also study associated cardiac MRI measures.

Methods
3T MRI scans were performed during HD in 12 patients to characterise the acute effect of HD on cerebral water content (T1 mapping), alongside previously reported results from the HD-REMODEL trial. MRI changes in brain structure (volumes and T1 of white (WM) and grey matter (GM), WM diffusion fractional anisotropy (FA) and mean diffusivity (MD)), perfusion, blood flow, and cardiac measures were compared between HD patients pre-dialysis and HVs (age and gender matched).

Results
WM T1 increased during HD (3.8±1.7%, p=0.0005). GM and WM volume (total intracranial volume (TIV)-corrected) were lower in HD compared to HVs (GMV/TIV: 0.37[0.34-0.41] vs. 0.42[0.42-0.44], WMV/TIV: 0.34±0.03 vs. 0.37±0.01, p=0.009). In HD, FA was lower and MD higher than HV (FA: 0.32±0.02 vs. 0.35±0.01, MD: 0.59±0.03 vs. 0.53±0.01, p<0.0001). . Higher MD and lower FA was seen in older participants, with steeper slopes in HD (MD: 0.003 vs. 0.0006 x10-3mm2/s/y p=0.003, FA: -0.001 vs -0.0003 units/y p<0.0001), suggestive of accelerated ageing. There were no differences between groups in age-related heart changes.

Conclusions
An acute increase in WM T1 during HD has been shown for the first time, reflecting a rise in brain water content. This is potentially caused by the development of an osmotic gradient across the blood-brain barrier due to slower diffusion of urea, and may contribute to acute symptoms and chronic pathological changes contributing to accelerated brain ageing in HD patients.

Citation

Cox, E. F., Gullapudi, V. R. L., Buchanan, C. E., White, K., Nicholas, R., Canaud, B., Taal, M. W., Selby, N. M., & Francis, S. T. (2025). Effect of haemodialysis on the brain and heart assessed using multiparametric MRI. Nephrology Dialysis Transplantation, Article gfaf117. https://doi.org/10.1093/ndt/gfaf117

• Journal Article Type: Article
• Acceptance Date: May 21, 2025
• Online Publication Date: Jul 9, 2025
• Publication Date: Jul 9, 2025
• Deposit Date: Jun 3, 2025
• Publicly Available Date: Jul 10, 2026
• Print ISSN: 0931-0509
• Electronic ISSN: 1460-2385
• Publisher: Oxford University Press
• Peer Reviewed: Peer Reviewed
• Article Number: gfaf117
• DOI: https://doi.org/10.1093/ndt/gfaf117
• Keywords: Brain ageing, Brain swelling, ESRD, Haemodialysis, Multiparametric magnetic resonance imaging
• Public URL: https://nottingham-repository.worktribe.com/output/49886938
• Publisher URL: https://academic.oup.com/ndt/advance-article/doi/10.1093/ndt/gfaf117/8195530