BSR guideline on the management of adults with systemic lupus erythematosus (SLE) 2018: Baseline multi-centre audit in the UK

Pearce, Fiona A.; Rutter, Megan; Sandhu, Ravinder; Batten, Rebecca L; Garner, Rozeena; Little, Jayne; Narayan, Nehal; Sharp, Charlotte A.; Bruce, Ian N.; Erb, Nicola; Griffiths, Bridget; Guest, Hannah; Macphie, Elizabeth; Packham, Jon; Hiley, Chris; Obrenovic, Karen; Rivett, Ali; Gordon, Caroline; Lanyon, Peter C.

Abstract

Objectives: To assess the baseline care provided to patients with SLE attending UK Rheumatology units, audited against standards derived from the recently published BSR guideline for the management of adults with SLE, the NICE technology appraisal for belimumab, and NHS England's clinical commissioning policy for rituximab. Methods: SLE cases attending outpatient clinics during any 4-week period between February and June 2018 were retrospectively audited to assess care at the preceding visit. The effect of clinical environment (general vs dedicated CTD/vasculitis clinic and specialized vs non-specialized centre) were tested. Bonferroni's correction was applied to the significance level. Results: Fifty-one units participated. We audited 1021 episodes of care in 1003 patients (median age 48 years, 74% diagnosed >5 years ago). Despite this disease duration, 286 (28.5%) patients had active disease. Overall in 497 (49%) clinic visits, it was recorded that the patient was receiving prednisolone, including in 28.5% of visits where disease was assessed as inactive. Low documented compliance (

Citation

Pearce, F. A., Rutter, M., Sandhu, R., Batten, R. L., Garner, R., Little, J., Narayan, N., Sharp, C. A., Bruce, I. N., Erb, N., Griffiths, B., Guest, H., Macphie, E., Packham, J., Hiley, C., Obrenovic, K., Rivett, A., Gordon, C., & Lanyon, P. C. (2021). BSR guideline on the management of adults with systemic lupus erythematosus (SLE) 2018: Baseline multi-centre audit in the UK. Rheumatology, 60(3), 1480-1490. https://doi.org/10.1093/rheumatology/keaa759

• Journal Article Type: Article
• Acceptance Date: Oct 13, 2020
• Online Publication Date: Dec 8, 2020
• Publication Date: Mar 1, 2021
• Deposit Date: Oct 14, 2020
• Publicly Available Date: Dec 9, 2021
• Journal: Rheumatology (United Kingdom)
• Electronic ISSN: 1462-0332
• Publisher: Oxford University Press
• Peer Reviewed: Peer Reviewed
• Volume: 60
• Issue: 3
• Pages: 1480-1490
• DOI: https://doi.org/10.1093/rheumatology/keaa759
• Keywords: Pharmacology (medical); Rheumatology
• Public URL: https://nottingham-repository.worktribe.com/output/4962818
• Publisher URL: https://academic.oup.com/rheumatology/advance-article-abstract/doi/10.1093/rheumatology/keaa759/6027899?redirectedFrom=fulltext
• Additional Information: This is a pre-copyedited, author-produced version of an article accepted for publication in Rheumatology following peer review. The version of record Fiona A Pearce, Megan Rutter, Ravinder Sandhu, Rebecca L Batten, Rozeena Garner, Jayne Little, Nehal Narayan, Charlotte A Sharp, Ian N Bruce, Nicola Erb, Bridget Griffiths, Hannah Guest, Elizabeth Macphie, Jon Packham, Chris Hiley, Karen Obrenovic, Ali Rivett, Caroline Gordon, Peter C Lanyon, BSR guideline on the management of adults with systemic lupus erythematosus (SLE) 2018: baseline multi-centre audit in the UK, Rheumatology, , keaa759 is available online at: https://doi.org/10.1093/rheumatology/keaa759