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Role of drugs used for chronic disease management on susceptibility and severity of COVID-19: A large case-control study

Yan, Huadong; Valdes, Ana M; Vijay, Amrita; Wang, Shanbo; Liang, Lili; Yang, Shiqing; Wang, Hongxia; Tan, Xiaoyan; Du, Jingyuan; Jin, Susu; Huang, Kecheng; Jiang, Fanrong; Zhang, Shun; Zheng, Nanhong; Hu, Yaoren; Cai, Ting; Aithal, Guruprasad P.

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Authors

Huadong Yan

Shanbo Wang

Lili Liang

Shiqing Yang

Hongxia Wang

Xiaoyan Tan

Jingyuan Du

Susu Jin

Kecheng Huang

Fanrong Jiang

Shun Zhang

Nanhong Zheng

Yaoren Hu

Ting Cai



Abstract

The study aimed to investigate whether specific medications used in the treatment chronic diseases affected either the development and/ or severity of COVID-19 in a cohort of 610 COVID-19 cases and 48,667 population-based controls from Zheijang, China. Using a cohort of 578 COVID-19 cases and 48,667 population-based controls from Zheijang, China we tested the role of usage of cardiovascular, antidiabetic and other medications on risk and severity of COVID 19. Analyses were adjusted for age, sex and BMI and for presence of relevant comorbidities. Individuals with hypertension taking calcium channel blockers had significantly increased risk [odds ratio (OR)= 1.73 (95% CI 1.2-2.3)] of manifesting symptoms of COVID-19 whereas those taking angiotensin receptor blockers and diuretics had significantly lower disease risk (OR=0.22; 95%CI 0.15-0.30 and OR=0.30; 95%CI 0.19-0.58 respectively). Among those with type 2 diabetes, dipeptidyl peptidase-4 inhibitors (OR= 6.02; 95% CI 2.3- 15.5) and insulin (OR= 2.71; 95% CI 1.6-5.5) were more and glucosidase inhibitors were less prevalent (OR= 0.11; 95% CI 0.1-0.3) among with COVID-19 patients. Drugs used in the treatment of hypertension and diabetes influence the risk of development of COVID-19, but, not its severity.

Citation

Yan, H., Valdes, A. M., Vijay, A., Wang, S., Liang, L., Yang, S., …Aithal, G. P. (2020). Role of drugs used for chronic disease management on susceptibility and severity of COVID-19: A large case-control study. Clinical Pharmacology and Therapeutics, 108(6), 1185-1194. https://doi.org/10.1002/cpt.2047

Journal Article Type Article
Acceptance Date Aug 27, 2020
Online Publication Date Sep 10, 2020
Publication Date 2020-12
Deposit Date Sep 3, 2020
Publicly Available Date Sep 11, 2021
Journal Clinical Pharmacology and Therapeutics
Print ISSN 0009-9236
Electronic ISSN 1532-6535
Publisher American Society for Clinical Pharmacology and Therapeutics
Peer Reviewed Peer Reviewed
Volume 108
Issue 6
Pages 1185-1194
DOI https://doi.org/10.1002/cpt.2047
Keywords COVID-19; Antihypertensive medications; Antidiabetic medications; Corticosteroids; Calcium channel blockers; Severity; Risk
Public URL https://nottingham-repository.worktribe.com/output/4880005
Publisher URL https://ascpt.onlinelibrary.wiley.com/doi/10.1002/cpt.2047

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