Preparation of Dried Amniotic Membrane for Corneal Repair

Hopkinson, Andrew; Britchford, Emily R.; Sidney, Laura E.

Abstract

Amniotic membrane transplantation is an established therapeutic and biological adjunct for several clinical situations, including treatment of diabetic foot ulcers and ocular surface disease. However, poorly standardized and validated clinical preparation and storage procedures can render the final product highly variable and an unpredictable biomaterial. We have therefore developed a novel, standardized method for processing and dry-preserving amniotic membrane, minimizing biochemical, compositional, and structure damage to produce a potentially superior membrane suitable for clinical use. The intellectual property associated with this methodology was patented by the University of Nottingham and licensed to NuVision® Biotherapies which formed the basis of the Tereo® manufacturing process which is used to manufacture Omnigen®.

Citation

Hopkinson, A., Britchford, E. R., & Sidney, L. E. (2020). Preparation of Dried Amniotic Membrane for Corneal Repair. In M. Ahearne (Ed.), Corneal Regeneration: Methods and Protocols (143-157). Springer US. https://doi.org/10.1007/978-1-0716-0599-8_10

• Online Publication Date: Jun 16, 2020
• Publication Date: Jun 16, 2020
• Deposit Date: Jul 14, 2020
• Pages: 143-157
• Series Title: Methods in Molecular Biology
• Series Number: 2145
• Book Title: Corneal Regeneration: Methods and Protocols
• ISBN: 9781071605981
• DOI: https://doi.org/10.1007/978-1-0716-0599-8_10
• Public URL: https://nottingham-repository.worktribe.com/output/4767294
• Publisher URL: https://link.springer.com/protocol/10.1007%2F978-1-0716-0599-8_10
• Contract Date: Feb 1, 2020