Is osteoarthritis a metabolic disorder?

Kluzek, S.; Newton, J. L.; Arden, N. K.

Abstract

Background

Obesity is associated with an increased risk of developing osteoarthritis (OA), even in non-weight bearing joints. High levels of adipose tissue-associated inflammation may explain this association.

Sources of data and areas of debate

Published evidence looking at the associations between components of Metabolic Syndrome (MetS) and knee, hip or hand OA and the higher mortality described with knee OA.

Emerging points

Development of MetS and OA shares a relationship with adipose tissue-associated inflammation. This review supports this inflammatory pathway being part of the shared mechanism behind obesity as a risk factor for OA and the recently described OA-associated increased mortality.

Timely areas for development

In an era of an obesity epidemic, this review identifies a need for well-designed cohort studies assessing early metabolic changes in populations at high risk of OA and MetS, and to identify risk factors for increased mortality in patients with OA.

Citation

Kluzek, S., Newton, J. L., & Arden, N. K. (2015). Is osteoarthritis a metabolic disorder?. British Medical Bulletin, 115(1), 111-121. https://doi.org/10.1093/bmb/ldv028

• Journal Article Type: Article
• Acceptance Date: May 19, 2015
• Online Publication Date: Jul 14, 2015
• Publication Date: 2015-09
• Deposit Date: May 20, 2020
• Journal: British Medical Bulletin
• Print ISSN: 0007-1420
• Electronic ISSN: 1471-8391
• Publisher: Oxford University Press (OUP)
• Peer Reviewed: Peer Reviewed
• Volume: 115
• Issue: 1
• Pages: 111-121
• DOI: https://doi.org/10.1093/bmb/ldv028
• Public URL: https://nottingham-repository.worktribe.com/output/4471234
• Publisher URL: https://academic.oup.com/bmb/article/115/1/111/260277