Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo

Rostam, Hassan M.; Fisher, Leanne E.; Hook, Andrew L.; Burroughs, Laurence; Luckett, Jeni C.; Figueredo, Grazziela P.; Mbadugha, Chidimma; Teo, Alvin C.K.; Latif, Arsalan; Kämmerling, Lisa; Day, Mitchell; Lawler, Karen; Barrett, David; Elsheikh, Somaia; Ilyas, Mohammad; Winkler, David A.; Alexander, Morgan R.; Ghaemmaghami, Amir M.

Abstract

© 2020 The Author(s) Implantation of medical devices can result in inflammation. A large library of polymers is screened, and a selection found to promote macrophage differentiation towards pro- or anti-inflammatory phenotypes. The bioinstructive properties of these materials are validated within a rodent model. By identifying novel materials with immune-instructive properties, the relationship between material-immune cell interactions could be investigated, and this offers exciting possibilities to design novel bioinstructive materials that can be used for numerous clinical applications including medical implants.

Citation

Rostam, H. M., Fisher, L. E., Hook, A. L., Burroughs, L., Luckett, J. C., Figueredo, G. P., Mbadugha, C., Teo, A. C., Latif, A., Kämmerling, L., Day, M., Lawler, K., Barrett, D., Elsheikh, S., Ilyas, M., Winkler, D. A., Alexander, M. R., & Ghaemmaghami, A. M. (2020). Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo. Matter, 2(6), 1564-1581. https://doi.org/10.1016/j.matt.2020.03.018

• Journal Article Type: Article
• Acceptance Date: Mar 23, 2020
• Online Publication Date: May 1, 2020
• Publication Date: Jun 3, 2020
• Deposit Date: May 14, 2020
• Publicly Available Date: May 14, 2020
• Journal: Matter
• Electronic ISSN: 2590-2393
• Publisher: Cell Press
• Peer Reviewed: Peer Reviewed
• Volume: 2
• Issue: 6
• Pages: 1564-1581
• DOI: https://doi.org/10.1016/j.matt.2020.03.018
• Public URL: https://nottingham-repository.worktribe.com/output/4434383
• Publisher URL: https://www.cell.com/matter/fulltext/S2590-2385(20)30131-4#%20