Prospective analysis of health-related quality of life after surgery for spinal metastases

Quraishi, Nasir A.; Pasku, Dritan; Koch, Jonathan E. J.; Arealis, Georgios; Boszczyk, Bronek M.; Edwards, Kimberley L.

Abstract

Purpose
Most spinal metastases are detected late, and thus, the impact of treatment on the health-related quality of life (HRQOL) is an important consideration. This study investigated the HRQOL following surgery for spinal metastases.

Methods
A prospective study of patients operated for symptomatic spinal metastases, at a single tertiary referral spine centre (2011–2013). Data were collected pre-operatively and up to 2 years following surgery (if alive). The HRQOL assessment was performed using recognised systems including the Frankel score (neurological status), EQ-5D, and the Oswestry Disability Index.

Results
A total of 199 patients were studied (median age 65 years, 43% (86) F; 57% (113) M). The Frankel score improved significantly after surgery in 69 patients (35%), worsened in 17 (8%), with 20/39 patients regaining the ability to walk (51%). All the HRQOL scores improved significantly following surgery. The complication rate was 27% and median survival 270 days, and 44 patients (22%) survived at 2 years.

Conclusions
This large prospective study showed that surgical treatment for spinal metastases significantly improved the HRQOL.

Citation

Quraishi, N. A., Pasku, D., Koch, J. E. J., Arealis, G., Boszczyk, B. M., & Edwards, K. L. (2020). Prospective analysis of health-related quality of life after surgery for spinal metastases. European Spine Journal, 29(12), 3163-3169. https://doi.org/10.1007/s00586-020-06396-6

• Journal Article Type: Article
• Acceptance Date: Mar 25, 2020
• Online Publication Date: Apr 7, 2020
• Publication Date: 2020-12
• Deposit Date: Apr 24, 2020
• Publicly Available Date: Apr 8, 2021
• Journal: European Spine Journal
• Print ISSN: 0940-6719
• Electronic ISSN: 1432-0932
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 29
• Issue: 12
• Pages: 3163-3169
• DOI: https://doi.org/10.1007/s00586-020-06396-6
• Keywords: Health Related Quality of Life (HRQOL); spine metastases; spine surgery; Frankel Score; EQ-5D; Oswestry Disability Index
• Public URL: https://nottingham-repository.worktribe.com/output/4332924
• Publisher URL: https://link.springer.com/article/10.1007/s00586-020-06396-6
• Additional Information: This is a post-peer-review, pre-copyedit version of an article published in European Spine Journal. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00586-020-06396-6.