Multivalent Crown Ether Receptors Enable Allosteric Regulation of Anion Exchange in an Fe4L6 Tetrahedron

von?Krbek, Larissa K. S.; Roberts, Derrick A.; Pilgrim, Ben S.; Schalley, Christoph A.; Nitschke, Jonathan R.

Abstract

We report a strategy for regulating the rate of internally bound anion exchange within an Fe4L6 metal–organic tetrahedron through external coordination of tripodal tris(alkylammonium) cations. The cage features three flexible 18‐crown‐6 receptors at each of its FeII vertices, facilitating strong tritopic interactions with tris(ammonium) cations to “cap” the vertices of the tetrahedron. This capping mechanism restricts the flexibility of the cage framework, thereby reducing the rate of anion exchange within its central cavity by 20‐fold. Thus, we demonstrate the first use of an externally bound multivalent effector to allosterically control internal guest binding in a molecular cage.

Citation

von Krbek, L. K. S., Roberts, D. A., Pilgrim, B. S., Schalley, C. A., & Nitschke, J. R. (2018). Multivalent Crown Ether Receptors Enable Allosteric Regulation of Anion Exchange in an Fe4L6 Tetrahedron. Angewandte Chemie International Edition, 57(43), 14121-14124. https://doi.org/10.1002/anie.201808534

• Journal Article Type: Article
• Acceptance Date: Oct 16, 2018
• Online Publication Date: Sep 27, 2018
• Publication Date: Oct 22, 2018
• Deposit Date: Feb 24, 2020
• Publicly Available Date: Mar 12, 2020
• Journal: Angewandte Chemie International Edition
• Print ISSN: 1433-7851
• Electronic ISSN: 1521-3773
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 57
• Issue: 43
• Pages: 14121-14124
• DOI: https://doi.org/10.1002/anie.201808534
• Public URL: https://nottingham-repository.worktribe.com/output/4026670
• Publisher URL: https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201808534
• Additional Information: This is the peer reviewed version of the following article: L. K. S. von Krbek, D. A. Roberts, B. S. Pilgrim, C. A. Schalley, J. R. Nitschke, Angew. Chem. Int. Ed. 2018, 57, 14121, which has been published in final form at https://doi.org/10.1002/anie.201808534. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.