Cortical thickness, cortical and subcortical volume, and white matter integrity in patients with their first episode of major depression

Han, Kyu-Man; Choi, Sunyoung; Jung, Jeyoung; Na, Kyoung-Sae; Yoon, Ho-Kyoung; Lee, Min-Soo; Ham, Byung-Joo

Abstract

Background

The uncertainty over the true morphological changes in brains with major depressive disorder (MDD) underlines the necessity of comprehensive studies with multimodal structural brain imaging analyses. This study aimed to evaluate the differences in cortical thickness, cortical and subcortical volume, and white matter integrity between first episode, medication-naïve MDD patients and healthy controls.

Methods

Subjects with their first episode of MDD whose illness duration had not exceeded 6 months (n=20) were enrolled in this study and were compared to age-, sex-, and education level-matched healthy controls (n=22). All participants were subjected to T1-weighted structural magnetic resonance imaging (MRI). We used an automated procedure of FreeSurfer and Tract-based spatial statistics (TBSS) to analyze differences in cortical thickness, cortical and subcortical volume, and white matter integrity between two groups.

Results

The patients with first episode MDD exhibited significantly reduced cortical volume in the caudal anterior cingulate gyrus (P

Citation

Han, K.-M., Choi, S., Jung, J., Na, K.-S., Yoon, H.-K., Lee, M.-S., & Ham, B.-J. (2014). Cortical thickness, cortical and subcortical volume, and white matter integrity in patients with their first episode of major depression. Journal of Affective Disorders, 155, 42-48. https://doi.org/10.1016/j.jad.2013.10.021

• Journal Article Type: Article
• Acceptance Date: Oct 14, 2013
• Online Publication Date: Oct 21, 2013
• Publication Date: Feb 1, 2014
• Deposit Date: May 22, 2020
• Journal: Journal of Affective Disorders
• Print ISSN: 0165-0327
• Electronic ISSN: 1573-2517
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 155
• Pages: 42-48
• DOI: https://doi.org/10.1016/j.jad.2013.10.021
• Keywords: Clinical Psychology; Psychiatry and Mental health
• Public URL: https://nottingham-repository.worktribe.com/output/3871049
• Publisher URL: https://www.sciencedirect.com/science/article/abs/pii/S0165032713007635
• Additional Information: This article is maintained by: Elsevier; Article Title: Cortical thickness, cortical and subcortical volume, and white matter integrity in patients with their first episode of major depression; Journal Title: Journal of Affective Disorders; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.jad.2013.10.021; Content Type: article; Copyright: Copyright © 2013 Elsevier B.V. All rights reserved.