Role of pseudotyped viruses in understanding epidemiology, pathogenesis and immunity of viral diseases affecting both horses and humans

Sedgwick, Rebecca L; Elbohy, Ola; Daly, Janet M

Abstract

In this review, we explore how pseudotyped viruses (PVs) are being applied to the study of viruses affecting both humans and horses. For the purposes of this review, we define PVs as non-replicative viruses with the core of one virus and the surface protein(s) of another and encapsulating a reporter gene such as luciferase. These ‘reporter’ PVs enable receptormediated entry into host cells to be quantified, and thus can be applied to study the initial stages of viral replication. They can also be used to test antiviral activity of compounds and measure envelope protein-specific antibodies in neutralisation tests.

Citation

Sedgwick, R. L., Elbohy, O., & Daly, J. M. (2024). Role of pseudotyped viruses in understanding epidemiology, pathogenesis and immunity of viral diseases affecting both horses and humans. Virology, 597, Article 110164. https://doi.org/10.1016/j.virol.2024.110164

• Journal Article Type: Article
• Acceptance Date: Jun 27, 2024
• Online Publication Date: Jul 2, 2024
• Publication Date: 2024-09
• Deposit Date: Jun 28, 2024
• Publicly Available Date: Jul 3, 2025
• Journal: Virology
• Print ISSN: 0042-6822
• Electronic ISSN: 0042-6822
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 597
• Article Number: 110164
• DOI: https://doi.org/10.1016/j.virol.2024.110164
• Keywords: pseudo; virus; pseudotyped
• Public URL: https://nottingham-repository.worktribe.com/output/36576840
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0042682224001855