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Urine Se concentration poorly predicts plasma Se concentration at sub-district scales in Zimbabwe, limiting its value as a biomarker of population Se status

Mutonhodza, Beaula; Dembedza, Mavis P.; Joy, Edward J. M.; Manzeke-Kangara, Muneta G.; Njovo, Handrea; Nyadzayo, Tasiana K.; Lark, R. Murray; Kalimbira, Alexander A.; Bailey, Elizabeth H.; Broadley, Martin R.; Matsungo, Tonderayi M.; Chopera, Prosper

Urine Se concentration poorly predicts plasma Se concentration at sub-district scales in Zimbabwe, limiting its value as a biomarker of population Se status Thumbnail


Authors

Beaula Mutonhodza

Mavis P. Dembedza

Edward J. M. Joy

Muneta G. Manzeke-Kangara

Handrea Njovo

Tasiana K. Nyadzayo

R. Murray Lark

Alexander A. Kalimbira

Tonderayi M. Matsungo

Prosper Chopera



Abstract

Introduction: The current study investigated the value of urine selenium (Se) concentration as a biomarker of population Se status in rural sub-Saharan Africa.

Method: Urine and plasma Se concentrations were measured among children aged 6–59 months (n = 608) and women of reproductive age (WRA, n = 781) living in rural Zimbabwe (Murehwa, Shamva, and Mutasa districts) and participating in a pilot national micronutrient survey. Selenium concentrations were measured by inductively coupled plasma-mass spectrometry (ICP-MS), and urine concentrations were corrected for hydration status.

Results: The median (Q1, Q3) urine Se concentrations were 8.4 μg/L (5.3, 13.5) and 10.5 μg/L (6.5, 15.2) in children and WRA, respectively. There was moderate evidence for a relationship between urine Se concentration and plasma Se concentration in children (p = 0.0236) and WRA (p = < 0.0001), but the relationship had poor predictive value. Using previously defined thresholds for optimal activity of iodothyronine deiodinase (IDI), there was an association between deficiency when indicated by plasma Se concentrations and urine Se concentrations among WRA, but not among children.

Discussion: Urine Se concentration poorly predicted plasma Se concentration at sub-district scales in Zimbabwe, limiting its value as a biomarker of population Se status in this context. Further research is warranted at wider spatial scales to determine the value of urine Se as a biomarker when there is greater heterogeneity in Se exposure.

Citation

Mutonhodza, B., Dembedza, M. P., Joy, E. J. M., Manzeke-Kangara, M. G., Njovo, H., Nyadzayo, T. K., Lark, R. M., Kalimbira, A. A., Bailey, E. H., Broadley, M. R., Matsungo, T. M., & Chopera, P. (2024). Urine Se concentration poorly predicts plasma Se concentration at sub-district scales in Zimbabwe, limiting its value as a biomarker of population Se status. Frontiers in Nutrition, 11, Article 1288748. https://doi.org/10.3389/fnut.2024.1288748

Journal Article Type Article
Acceptance Date Jan 17, 2024
Online Publication Date Feb 7, 2024
Publication Date Feb 7, 2024
Deposit Date Apr 3, 2024
Publicly Available Date Apr 4, 2024
Journal Frontiers in Nutrition
Electronic ISSN 2296-861X
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 11
Article Number 1288748
DOI https://doi.org/10.3389/fnut.2024.1288748
Keywords selenium deficiency, dietary selenium intake, iodothyronine deiodinase, micronutrient surveillance, estimated average requirement, biomarkers
Public URL https://nottingham-repository.worktribe.com/output/31881317
Publisher URL https://www.frontiersin.org/articles/10.3389/fnut.2024.1288748/full

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Urine Se concentration poorly predicts plasma Se concentration at sub-district scales in Zimbabwe, limiting its value as a biomarker of population Se status (1.1 Mb)
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Copyright Statement
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.





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