Maternal nutrient restriction during early to mid gestation alters the relationship between insulin-like growth factor I and bodyweight at term in fetal sheep

Heasman, L.; Brameld, J.; Mostyn, A.; Budge, H.; Dawson, J.; Buttery, P.; Stephenson, T.; Symonds, M. E.

Abstract

The present study was designed to determine whether altered placental size, as a consequence of maternal nutrient restriction in sheep between 28 and 77 days gestation, is associated with a modified relationship between fetal weight or dimensions and plasma insulin-like growth factor (IGF) I concentration or abundance of hepatic IGF-I and IGF-II mRNA close to term. Singleton-bearing ewes consumed either 1.2× (controls, n = 19) or 0.5× (nutrient restricted, n = 28) their metabolizable energy (ME) requirements from 28 to 77 days gestation, after which all ewes were fed in order to fully meet their ME requirements for maintenance and pregnancy. Close to term (145 ± 1 days) plasma IGF-I concentration in cord blood was similar between groups, but only significantly correlated with fetal bodyweight, thoracic circumference, crown-rump length and lean body mass in lambs born to control (r2 = 0.38, 0.76, 0.33, 0.42; P

Citation

Heasman, L., Brameld, J., Mostyn, A., Budge, H., Dawson, J., Buttery, P., …Symonds, M. E. (2000). Maternal nutrient restriction during early to mid gestation alters the relationship between insulin-like growth factor I and bodyweight at term in fetal sheep. Reproduction, Fertility and Development, 12(7-8), 345-350. https://doi.org/10.1071/RD00115

• Journal Article Type: Article
• Publication Date: Dec 1, 2000
• Deposit Date: Apr 27, 2021
• Journal: Reproduction, Fertility and Development
• Print ISSN: 1031-3613
• Publisher: CSIRO Publishing
• Peer Reviewed: Peer Reviewed
• Volume: 12
• Issue: 7-8
• Pages: 345-350
• DOI: https://doi.org/10.1071/RD00115
• Public URL: https://nottingham-repository.worktribe.com/output/3185919
• Publisher URL: https://www.publish.csiro.au/rd/RD00115