Biomimetic tissues on a chip for drug discovery

Ghaemmaghami, Amir M.; Hancock, Matthew J.; Harrington, Helen; Kaji, Hirokazu; Khademhosseini, Ali

Abstract

Developing biologically relevant models of human tissues and organs is an important enabling step for disease modeling and drug discovery. Recent advances in tissue engineering, biomaterials and microfluidics have led to the development of microscale functional units of such models also referred to as 'organs on a chip'. In this review, we provide an overview of key enabling technologies and highlight the wealth of recent work regarding on-chip tissue models. In addition, we discuss the current challenges and future directions of organ-on-chip development. © 2011 Elsevier Ltd All rights reserved.

Citation

Ghaemmaghami, A. M., Hancock, M. J., Harrington, H., Kaji, H., & Khademhosseini, A. (2012). Biomimetic tissues on a chip for drug discovery. Drug Discovery Today, 17(3-4), 173-181. https://doi.org/10.1016/j.drudis.2011.10.029

• Journal Article Type: Review
• Online Publication Date: Nov 6, 2011
• Publication Date: Feb 1, 2012
• Deposit Date: Jan 3, 2023
• Journal: Drug Discovery Today
• Print ISSN: 1359-6446
• Electronic ISSN: 1878-5832
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 17
• Issue: 3-4
• Pages: 173-181
• DOI: https://doi.org/10.1016/j.drudis.2011.10.029
• Public URL: https://nottingham-repository.worktribe.com/output/3097509
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S1359644611003941?via%3Dihub