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Working-for-Food Behaviors: A Preclinical Study in Prader-Willi Mutant Mice

Lassi, Glenda; Maggi, Silvia; Balzani, Edoardo; Cosentini, Ilaria; Garcia-Garcia, Celina; Tucci, Valter

Authors

Glenda Lassi

Edoardo Balzani

Ilaria Cosentini

Celina Garcia-Garcia

Valter Tucci



Abstract

Abnormal feeding behavior is one of the main symptoms of Prader-Willi syndrome (PWS). By studying a PWS mouse
mutant line, which carries a paternally inherited deletion of the small nucleolar RNA 116 (Snord116), we observed significant changes
in working-for-food behavioral responses at various timescales. In particular, we report that PWS mutant mice show a significant delay
compared to wild-type littermate controls in responding to both hour-scale and seconds-to-minutes-scale time intervals. This timing
shift in mutant mice is associated with better performance in the working-for-food task, and results in better decision making in these
mutant mice. The results of our study reveal a novel aspect of the organization of feeding behavior, and advance the understanding of
the interplay between the metabolic functions and cognitive mechanisms of PWS.

Citation

Lassi, G., Maggi, S., Balzani, E., Cosentini, I., Garcia-Garcia, C., & Tucci, V. (2016). Working-for-Food Behaviors: A Preclinical Study in Prader-Willi Mutant Mice. Genetics, 204(3), 1129-1138. https://doi.org/10.1534/genetics.116.192286

Journal Article Type Article
Acceptance Date Sep 26, 2016
Online Publication Date Sep 26, 2016
Publication Date 2016-11
Deposit Date Nov 5, 2019
Journal Genetics
Print ISSN 0016-6731
Electronic ISSN 1943-2631
Publisher Genetics Society of America
Peer Reviewed Peer Reviewed
Volume 204
Issue 3
Pages 1129-1138
DOI https://doi.org/10.1534/genetics.116.192286
Public URL https://nottingham-repository.worktribe.com/output/3058428
Publisher URL https://www.genetics.org/content/204/3/1129