HEART UK consensus statement on Lipoprotein(a): A call to action

Cegla, Jaimini; Neely, R Dermot G; France, Michael; Ferns, Gordon; Byrne, Chris D; Halcox, Julian; Datta, Dev; Capps, Nigel; Shoulder, Carol; Qureshi, Nadeem; Rees, Alan; Main, Linda; Cramb, Robert; Viljoen, Adie; Paynel, Jules; Soran, Handrean; for the HEART UK Medical, Scientific and Research Committee

Abstract

Lipoprotein(a), Lp(a), is a modified atherogenic low-density lipoprotein particle that contains apolipoprotein(a). Its levels are highly heritable and variable in the population. This consensus statement by HEART UK is based on the evidence that Lp(a) is an independent cardiovascular disease (CVD) risk factor, provides recommendations for its measurement in clinical practice and reviews current and emerging therapeutic strategies to reduce CVD risk. Ten statements summarise the most salient points for practitioners and patients with high Lp(a).

HEART UK recommends that Lp(a) is measured in adults as follows: 1) those with a personal or family history of premature atherosclerotic CVD; 2) those with first-degree relatives who have Lp(a) levels >200 nmol/l; 3) patients with familial hypercholesterolemia; 4) patients with calcific aortic valve stenosis and 5) those with borderline (but

Citation

Cegla, J., Neely, R. D. G., France, M., Ferns, G., Byrne, C. D., Halcox, J., Datta, D., Capps, N., Shoulder, C., Qureshi, N., Rees, A., Main, L., Cramb, R., Viljoen, A., Paynel, J., Soran, H., & for the HEART UK Medical, Scientific and Research Committee. (2019). HEART UK consensus statement on Lipoprotein(a): A call to action. Atherosclerosis, 291, 62-70. https://doi.org/10.1016/j.atherosclerosis.2019.10.011

• Journal Article Type: Article
• Acceptance Date: Oct 10, 2019
• Online Publication Date: Oct 14, 2019
• Publication Date: 2019-12
• Deposit Date: Oct 11, 2019
• Publicly Available Date: Nov 12, 2019
• Journal: Atherosclerosis
• Print ISSN: 0021-9150
• Electronic ISSN: 1879-1484
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 291
• Pages: 62-70
• DOI: https://doi.org/10.1016/j.atherosclerosis.2019.10.011
• Keywords: Lipoprotein(a), Lp(a), lipid, hyperlipidemia, cardiovascular risk, myocardial infarction, stroke.
• Public URL: https://nottingham-repository.worktribe.com/output/2806978
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S002191501931528X
• Contract Date: Oct 11, 2019