Identification of neurobehavioural symptom groups based on shared brain mechanisms

Ing, Alex; S?mann, Philipp G.; Chu, Congying; Tay, Nicole; Biondo, Francesca; Jia, Tianye; Wolfers, Thomas; Desrivi�res, Sylvane; Robert, Gabriel; Banaschewski, Tobias; Bokde, Arun L.W.; Bromberg, Uli; B�chel, Christian; Conrod, Patricia; Fadai, Tahmine; Flor, Herta; Frouin, Vincent; Garavan, Hugh; Spechler, Philip A.; Gowland, Penny; Grimmer, Yvonne; Ittermann, Bernd; Kappel, Viola; Heinz, Andreas; Martinot, Jean-Luc; Millenet, Sabina; Nees, Frauke; van Noort, Betteke; Orfanos, Dimitri Papadopoulos; Martinot, Marie-Laure Paill�re; Penttil�, Jani; Poustka, Luise; Meyer-Lindenberg, Andreas; Quinlan, Erin Burke; Smolka, Michael N.; Stringaris, Argyris; Struve, Maren; Veer, Ilya M.; Whelan, Robert; Walter, Henrik; Andreassen, Ole A.; Agartz, Ingrid; Lemaitre, Herv�; Barker, Edward D.; Ashburner, John; Binder, Elisabeth; Buitelaar, Jan; Marquand, Andre; Robbins, Trevor W.; Schumann, Gunter; IMAGEN Consortium

Abstract

Most psychopathological disorders develop in adolescence. The biological basis for this development is poorly understood. To enhance diagnostic characterization and develop improved targeted interventions, it is critical to identify behavioural symptom groups that share neural substrates. We ran analyses to find relationships between behavioural symptoms and neuroimaging measures of brain structure and function in adolescence. We found two symptom groups, consisting of anxiety/depression and executive dysfunction symptoms, respectively, that correlated with distinct sets of brain regions and inter-regional connections, measured by structural and functional neuroimaging modalities. We found that the neural correlates of these symptom groups were present before behavioural symptoms had developed. These neural correlates showed case–control differences in corresponding psychiatric disorders, depression and attention deficit hyperactivity disorder in independent clinical samples. By characterizing behavioural symptom groups based on shared neural mechanisms, our results provide a framework for developing a classification system for psychiatric illness that is based on quantitative neurobehavioural measures.

Citation

Ing, A., Sӓmann, P. G., Chu, C., Tay, N., Biondo, F., Jia, T., Wolfers, T., Desrivières, S., Robert, G., Banaschewski, T., Bokde, A. L., Bromberg, U., Büchel, C., Conrod, P., Fadai, T., Flor, H., Frouin, V., Garavan, H., Spechler, P. A., Gowland, P., …IMAGEN Consortium. (2019). Identification of neurobehavioural symptom groups based on shared brain mechanisms. Nature Human Behaviour, 3, 1306–1318. https://doi.org/10.1038/s41562-019-0738-8

• Journal Article Type: Article
• Acceptance Date: Aug 22, 2019
• Online Publication Date: Oct 7, 2019
• Publication Date: Oct 7, 2019
• Deposit Date: Oct 10, 2019
• Publicly Available Date: Apr 8, 2020
• Journal: Nature Human Behaviour
• Electronic ISSN: 2397-3374
• Publisher: Nature Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 3
• Pages: 1306–1318
• DOI: https://doi.org/10.1038/s41562-019-0738-8
• Public URL: https://nottingham-repository.worktribe.com/output/2798422
• Publisher URL: https://www.nature.com/articles/s41562-019-0738-8
• Additional Information: Received: 13 May 2019; Accepted: 22 August 2019; First Online: 7 October 2019; : T.B. served in an advisory or consultancy role for Lundbeck, Medice, Neurim Pharmaceuticals, Oberberg GmbH and Shire. He received conference support or a speaker’s fee from Lilly, Medice, Novartis and Shire. He has been involved in clinical trials conducted by Shire and Viforpharma. He received royalties from Hogrefe, Kohlhammer, CIP Medien and Oxford University Press. The present work is unrelated to the above grants and relationships. E.D.B. received honoraria from General Electric Healthcare for teaching on scanner programming courses and acts as a consultant for IXICO. O.A.A. received a speaker’s honorarium from Lundbeck. G.R. received financial support from scientific meetings (Janssen & Janssen, Otsuka−Lundbeck). A.M.-L. received consultant fees from Boehringer Ingelheim, Brainsway, Elsevier, Lundbeck Int. Neuroscience Foundation and Science Advances. The other authors declare no competing interests.
• Contract Date: Oct 10, 2019