Use of 31P magnetisation transfer magnetic resonance spectroscopy to measure ATP changes after 670 nm transcranial photobiomodulation in older adults

Fear, Elizabeth J.; Torkelsen, Frida H.; Zamboni, Elisa; Chen, Kuan‐Ju; Scott, Martin; Jeffery, Glenn; Baseler, Heidi; Kennerley, Aneurin J.

Abstract

Mitochondrial function declines with age, and many pathological processes in neurodegenerative diseases stem from this dysfunction when mitochondria fail to produce the necessary energy required. Photobiomodulation (PBM), long‐wavelength light therapy, has been shown to rescue mitochondrial function in animal models and improve human health, but clinical uptake is limited due to uncertainty around efficacy and the mechanisms responsible. Using 31P magnetisation transfer magnetic resonance spectroscopy (MT‐MRS) we quantify, for the first time, the effects of 670 nm PBM treatment on healthy ageing human brains. We find a significant increase in the rate of ATP synthase flux in the brain after PBM in a cohort of older adults. Our study provides initial evidence of PBM therapeutic efficacy for improving mitochondrial function and restoring ATP flux with age, but recognises that wider studies are now required to confirm any resultant cognitive benefits.

Citation

Fear, E. J., Torkelsen, F. H., Zamboni, E., Chen, K., Scott, M., Jeffery, G., Baseler, H., & Kennerley, A. J. (2023). Use of 31P magnetisation transfer magnetic resonance spectroscopy to measure ATP changes after 670 nm transcranial photobiomodulation in older adults. Aging Cell, 22(11), Article e14005. https://doi.org/10.1111/acel.14005

• Journal Article Type: Article
• Acceptance Date: Sep 22, 2023
• Online Publication Date: Oct 6, 2023
• Publication Date: 2023-11
• Deposit Date: Dec 19, 2023
• Publicly Available Date: Dec 19, 2023
• Journal: Aging Cell
• Print ISSN: 1474-9718
• Electronic ISSN: 1474-9726
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 22
• Issue: 11
• Article Number: e14005
• DOI: https://doi.org/10.1111/acel.14005
• Keywords: ageing brain, magnetisation transfer, cell metabolism, photobiomodulation, 31P magnetic resonance spectroscopy
• Public URL: https://nottingham-repository.worktribe.com/output/25953444
• Publisher URL: https://onlinelibrary.wiley.com/doi/10.1111/acel.14005
• Additional Information: Received: 2023-05-23; Accepted: 2023-09-22; Published: 2023-10-06