Association of gut-related metabolites with respiratory symptoms in COVID-19: A proof-of-concept study

Israr, Muhammad Zubair; Ibrahim, Wadah; Salzano, Andrea; Sarmad, Sarir; Wilde, Michael J.; Cordell, Rebecca L.; Greening, Neil J.; Brightling, Christopher E.; Siddiqui, Salman; Suzuki, Toru

Abstract

Gut-related metabolites have been linked with respiratory disease. The crosstalk between the gut and lungs suggests that gut health may be compromised in COVID-19. The aims of the present study were to analyze a panel of gut-related metabolites (acetyl-L-carnitine, betaine, choline, L-carnitine, trimethylamine, and trimethylamine N-oxide) in patients with COVID-19, matched with healthy individuals and patients with non-COVID-19 respiratory symptoms. As results, metabolites from this panel were impaired in patients with COVID-19 and were associated with the symptoms of breathlessness and temperature, and it was possible to differentiate between COVID-19 and asthma. Preliminary results showed that lower levels of betaine appeared to be associated with poor outcomes in patients with COVID-19, suggesting betaine as a marker of gut microbiome health.

Citation

Israr, M. Z., Ibrahim, W., Salzano, A., Sarmad, S., Wilde, M. J., Cordell, R. L., Greening, N. J., Brightling, C. E., Siddiqui, S., & Suzuki, T. (2022). Association of gut-related metabolites with respiratory symptoms in COVID-19: A proof-of-concept study. Nutrition, 96, Article 111585. https://doi.org/10.1016/j.nut.2021.111585

• Journal Article Type: Article
• Acceptance Date: Dec 27, 2021
• Online Publication Date: Jan 5, 2022
• Publication Date: 2022-04
• Deposit Date: Nov 3, 2023
• Publicly Available Date: Nov 29, 2023
• Journal: Nutrition
• Print ISSN: 0899-9007
• Electronic ISSN: 1873-1244
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 96
• Article Number: 111585
• DOI: https://doi.org/10.1016/j.nut.2021.111585
• Keywords: Gut microbiota, COVID-19, Respiratory, Metabolomics
• Public URL: https://nottingham-repository.worktribe.com/output/25395622
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0899900721004470?via%3Dihub