Carlo Lisci
Photoperiodic changes in adiposity increase sensitivity of female Siberian hamsters to systemic VGF derived peptide TLQP-21
Lisci, Carlo; Lewis, Jo E.; Daniel, Zoe C.T.R.; Stevenson, Tyler J.; Monnier, Chloe; Marshall, Hayley J.; Fowler, Maxine; Ferri, Gian-Luca; Ebling, Francis J.P.; Cocco, Cristina; Jethwa, Preeti H.
Authors
Jo E. Lewis
Zoe C.T.R. Daniel
Tyler J. Stevenson
Chloe Monnier
Hayley J. Marshall
Maxine Fowler
Gian-Luca Ferri
Francis J.P. Ebling
Cristina Cocco
Dr PREETI JETHWA PREETI.JETHWA@NOTTINGHAM.AC.UK
Assistant Professor
Abstract
TLQP-21, a peptide encoded by the highly conserved vgf gene, is expressed in neuroendocrine cells and has been the most prominent VGF-derived peptide studied in relation to control of energy balance. The recent discovery that TLQP-21 is the natural agonist for the complement 3a receptor 1 (C3aR1) has revived interest in this peptide as a potential drug target for obesity. We have investigated its function in Siberian hamsters (Phodopus sungorus), a rodent that displays natural seasonal changes in body weight and adiposity as an adaptation to survive winter. We have previously shown that intracerebroventricular administration of TLQP-21 reduced food intake and body weight in hamsters in their long-day fat state. The aim of our current study was to determine the systemic actions of TLQP-21 on food intake, energy expenditure and body weight, and to establish whether adiposity affected these responses. Peripheral infusion of TLQP-21 (1mg/kg/day for 7 days) in lean hamsters exposed to short photoperiods (SP) reduced cumulative food intake in the home cage (p≤0.05), and intake when measured in metabolic cages (P≤0.01). Energy expenditure was significantly increased (p
Citation
Lisci, C., Lewis, J. E., Daniel, Z. C., Stevenson, T. J., Monnier, C., Marshall, H. J., …Jethwa, P. H. (2019). Photoperiodic changes in adiposity increase sensitivity of female Siberian hamsters to systemic VGF derived peptide TLQP-21. PLoS ONE, 14(8), Article e0221517. https://doi.org/10.1371/journal.pone.0221517
Journal Article Type | Article |
---|---|
Acceptance Date | Aug 1, 2019 |
Online Publication Date | Aug 29, 2019 |
Publication Date | Aug 29, 2019 |
Deposit Date | Aug 20, 2019 |
Publicly Available Date | Mar 28, 2024 |
Journal | PLOS ONE |
Electronic ISSN | 1932-6203 |
Publisher | Public Library of Science |
Peer Reviewed | Peer Reviewed |
Volume | 14 |
Issue | 8 |
Article Number | e0221517 |
DOI | https://doi.org/10.1371/journal.pone.0221517 |
Keywords | VGF; TLQP-21; C3aR1; Photoperiod; body weight; Siberian hamsters; energy |
Public URL | https://nottingham-repository.worktribe.com/output/2450205 |
Publisher URL | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0221517 |
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Photoperiodic changes in adiposity
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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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