Photoperiodic changes in adiposity increase sensitivity of female Siberian hamsters to systemic VGF derived peptide TLQP-21

Lisci, Carlo; Lewis, Jo E.; Daniel, Zoe C.T.R.; Stevenson, Tyler J.; Monnier, Chloe; Marshall, Hayley J.; Fowler, Maxine; Ferri, Gian-Luca; Ebling, Francis J.P.; Cocco, Cristina; Jethwa, Preeti H.

Abstract

TLQP-21, a peptide encoded by the highly conserved vgf gene, is expressed in neuroendocrine cells and has been the most prominent VGF-derived peptide studied in relation to control of energy balance. The recent discovery that TLQP-21 is the natural agonist for the complement 3a receptor 1 (C3aR1) has revived interest in this peptide as a potential drug target for obesity. We have investigated its function in Siberian hamsters (Phodopus sungorus), a rodent that displays natural seasonal changes in body weight and adiposity as an adaptation to survive winter. We have previously shown that intracerebroventricular administration of TLQP-21 reduced food intake and body weight in hamsters in their long-day fat state. The aim of our current study was to determine the systemic actions of TLQP-21 on food intake, energy expenditure and body weight, and to establish whether adiposity affected these responses. Peripheral infusion of TLQP-21 (1mg/kg/day for 7 days) in lean hamsters exposed to short photoperiods (SP) reduced cumulative food intake in the home cage (p≤0.05), and intake when measured in metabolic cages (P≤0.01). Energy expenditure was significantly increased (p

Citation

Lisci, C., Lewis, J. E., Daniel, Z. C., Stevenson, T. J., Monnier, C., Marshall, H. J., Fowler, M., Ferri, G.-L., Ebling, F. J., Cocco, C., & Jethwa, P. H. (2019). Photoperiodic changes in adiposity increase sensitivity of female Siberian hamsters to systemic VGF derived peptide TLQP-21. PLoS ONE, 14(8), Article e0221517. https://doi.org/10.1371/journal.pone.0221517

• Journal Article Type: Article
• Acceptance Date: Aug 1, 2019
• Online Publication Date: Aug 29, 2019
• Publication Date: Aug 29, 2019
• Deposit Date: Aug 20, 2019
• Publicly Available Date: Aug 21, 2019
• Journal: PLOS ONE
• Electronic ISSN: 1932-6203
• Publisher: Public Library of Science
• Peer Reviewed: Peer Reviewed
• Volume: 14
• Issue: 8
• Article Number: e0221517
• DOI: https://doi.org/10.1371/journal.pone.0221517
• Keywords: VGF; TLQP-21; C3aR1; Photoperiod; body weight; Siberian hamsters; energy
• Public URL: https://nottingham-repository.worktribe.com/output/2450205
• Publisher URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0221517
• Contract Date: Aug 20, 2019