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Photoperiodic changes in adiposity increase sensitivity of female Siberian hamsters to systemic VGF derived peptide TLQP-21

Lisci, Carlo; Lewis, Jo E.; Daniel, Zoe C.T.R.; Stevenson, Tyler J.; Monnier, Chloe; Marshall, Hayley J.; Fowler, Maxine; Ferri, Gian-Luca; Ebling, Francis J.P.; Cocco, Cristina; Jethwa, Preeti H.

Photoperiodic changes in adiposity increase sensitivity of female Siberian hamsters to systemic VGF derived peptide TLQP-21 Thumbnail


Authors

Carlo Lisci

Jo E. Lewis

Zoe C.T.R. Daniel

Tyler J. Stevenson

Chloe Monnier

Hayley J. Marshall

Maxine Fowler

Gian-Luca Ferri

Francis J.P. Ebling

Cristina Cocco



Abstract

TLQP-21, a peptide encoded by the highly conserved vgf gene, is expressed in neuroendocrine cells and has been the most prominent VGF-derived peptide studied in relation to control of energy balance. The recent discovery that TLQP-21 is the natural agonist for the complement 3a receptor 1 (C3aR1) has revived interest in this peptide as a potential drug target for obesity. We have investigated its function in Siberian hamsters (Phodopus sungorus), a rodent that displays natural seasonal changes in body weight and adiposity as an adaptation to survive winter. We have previously shown that intracerebroventricular administration of TLQP-21 reduced food intake and body weight in hamsters in their long-day fat state. The aim of our current study was to determine the systemic actions of TLQP-21 on food intake, energy expenditure and body weight, and to establish whether adiposity affected these responses. Peripheral infusion of TLQP-21 (1mg/kg/day for 7 days) in lean hamsters exposed to short photoperiods (SP) reduced cumulative food intake in the home cage (p≤0.05), and intake when measured in metabolic cages (P≤0.01). Energy expenditure was significantly increased (p

Citation

Lisci, C., Lewis, J. E., Daniel, Z. C., Stevenson, T. J., Monnier, C., Marshall, H. J., …Jethwa, P. H. (2019). Photoperiodic changes in adiposity increase sensitivity of female Siberian hamsters to systemic VGF derived peptide TLQP-21. PLoS ONE, 14(8), Article e0221517. https://doi.org/10.1371/journal.pone.0221517

Journal Article Type Article
Acceptance Date Aug 1, 2019
Online Publication Date Aug 29, 2019
Publication Date Aug 29, 2019
Deposit Date Aug 20, 2019
Publicly Available Date Mar 28, 2024
Journal PLOS ONE
Electronic ISSN 1932-6203
Publisher Public Library of Science
Peer Reviewed Peer Reviewed
Volume 14
Issue 8
Article Number e0221517
DOI https://doi.org/10.1371/journal.pone.0221517
Keywords VGF; TLQP-21; C3aR1; Photoperiod; body weight; Siberian hamsters; energy
Public URL https://nottingham-repository.worktribe.com/output/2450205
Publisher URL https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0221517

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