Cross-sectional study of reversible airway obstruction in LAM: better evidence is needed for bronchodilator and inhaled steroid use

Johnson, Jan; Johnson, Simon R

Abstract

Lymphangioleiomyomatosis can be associated with reversible airflow obstruction and although no guidelines around reversibility testing or inhaled therapy exist, many patients receive bronchodilators and inhaled corticosteroids. To better identify those who may benefit, we examined bronchodilator reversibility and inhaled therapy in a national cohort of 213 subjects. 20% of those tested had airway reversibility by standard criteria. 55% of patients used 13 different combinations of bronchodilators and inhaled corticosteroids. Increasing inhaler classes were associated with reversibility and more rapid FEV1 decline. Reversibility testing should be performed in all patients and inhaled therapy should be formally studied.

Citation

Johnson, J., & Johnson, S. R. (2019). Cross-sectional study of reversible airway obstruction in LAM: better evidence is needed for bronchodilator and inhaled steroid use. Thorax, 74(10), 999-1002. https://doi.org/10.1136/thoraxjnl-2019-213338

• Journal Article Type: Article
• Acceptance Date: Jul 5, 2019
• Online Publication Date: Jul 30, 2019
• Publication Date: 2019-10
• Deposit Date: Aug 7, 2019
• Publicly Available Date: Aug 12, 2019
• Journal: Thorax
• Print ISSN: 0040-6376
• Electronic ISSN: 1468-3296
• Publisher: BMJ Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 74
• Issue: 10
• Pages: 999-1002
• DOI: https://doi.org/10.1136/thoraxjnl-2019-213338
• Keywords: Pulmonary and Respiratory Medicine
• Public URL: https://nottingham-repository.worktribe.com/output/2402633
• Publisher URL: https://thorax.bmj.com/content/early/2019/07/30/thoraxjnl-2019-213338
• Additional Information: This article has been accepted for publication in [Journal, Year]following peer review, and the Version of Record can be accessed online at http://dx.doi.org/10.1136/thoraxjnl-2019-213338.; © Authors (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.
• Contract Date: Aug 7, 2019