Immobilization of saponin on chitosan Milli-particles for Type II diabetic treatment

Yew, Maxine; Lim, Chang Nong; Liam, Boon Aik; Koh, Kai Seng; Lim, Siew Shee; Hiew, Billie; Fu, Ju Yen

Abstract

Type II diabetes mellitus (T2DM) has caused an adverse impact on the health of more than a tenth of the Malaysian population. Saponin is a traditional herbal extract found to be effective in treating T2DM with milder toxicity, which makes it a good alternative to conventional anti-diabetic drugs with side effects. This research develops an effective drug delivery vehicle to transport the saponin extract via chitosan milli-particles (CPs) for targeted release in the digestive system. Saponin was loaded onto the CPs via electrostatic interaction following the surface charge alteration of the CPs. Swelling tests and an in vitro study based on simulated gastrointestinal conditions were conducted on the saponin-immobilized CPs (SICPs). The release of saponin from its carrier is attributed to Fickian diffusion and swelling of the chitosan milli-particle matrix at pH 1.2 and 6.8.

Citation

Yew, M., Lim, C. N., Liam, B. A., Koh, K. S., Lim, S. S., Hiew, B., & Fu, J. Y. (2023). Immobilization of saponin on chitosan Milli-particles for Type II diabetic treatment. Materials Letters, 348, Article 134686. https://doi.org/10.1016/j.matlet.2023.134686

• Journal Article Type: Article
• Acceptance Date: Jun 2, 2023
• Online Publication Date: Jun 5, 2023
• Publication Date: Oct 1, 2023
• Deposit Date: Jul 25, 2023
• Publicly Available Date: Jul 26, 2023
• Journal: Materials Letters
• Print ISSN: 0167-577X
• Electronic ISSN: 1873-4979
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 348
• Article Number: 134686
• DOI: https://doi.org/10.1016/j.matlet.2023.134686
• Keywords: Milli-fluidic; Chitosan; Saponin; Diabetes; Biomaterial; Surfaces
• Public URL: https://nottingham-repository.worktribe.com/output/23220072
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0167577X23008716?via%3Dihub
• Additional Information: This article is maintained by: Elsevier; Article Title: Immobilization of saponin on chitosan Milli-particles for Type II diabetic treatment; Journal Title: Materials Letters; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.matlet.2023.134686; Content Type: article; Copyright: © 2023 The Authors. Published by Elsevier B.V.