Jamie R. Bhagwan
Modeling Hypertrophic Cardiomyopathy: Mechanistic Insights and Pharmacological Intervention
Bhagwan, Jamie R.; Smith, James G.W.; Mosqueira, Diogo; Smith, James G W; Bhagwan, Jamie R; Denning, Chris
Authors
James G.W. Smith
Diogo Mosqueira
James G W Smith
Jamie R Bhagwan
Professor CHRIS DENNING chris.denning@nottingham.ac.uk
PROFESSOR OF STEM CELL BIOLOGY
Abstract
HCM is a prevalent and complex disease governed by multiple molecular mechanisms, and there is currently no efficient cure. New treatment strategies are under development, and several drugs are reaching the final stages of clinical trials, with partial efficacy.
HCM disease models vary in complexity. Furthermore, they are limited by sample availability, demanding logistics, preparation artefacts, oversimplicity, and species-differences relative to the human cardiovascular physiology, often producing conflicting results.
Application of genome-editing technology to hPSCs enables unlimited isogenic sets of heart cells in which the primary mutation is the only change, allowing elucidation of disease phenotypes and genetic causation.
Uncovering new disease mechanisms and targets will pave the way to more efficient HCM therapeutics.
Citation
Bhagwan, J. R., Smith, J. G., Mosqueira, D., Smith, J. G. W., Bhagwan, J. R., & Denning, C. (2019). Modeling Hypertrophic Cardiomyopathy: Mechanistic Insights and Pharmacological Intervention. Trends in Molecular Medicine, 25(9), 775-790. https://doi.org/10.1016/j.molmed.2019.06.005
Journal Article Type | Article |
---|---|
Acceptance Date | Jun 19, 2019 |
Online Publication Date | Jul 17, 2019 |
Publication Date | 2019-09 |
Deposit Date | Jul 5, 2019 |
Publicly Available Date | Jul 18, 2020 |
Journal | Trends in Molecular Medicine |
Print ISSN | 1471-4914 |
Electronic ISSN | 1471-499X |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 25 |
Issue | 9 |
Pages | 775-790 |
DOI | https://doi.org/10.1016/j.molmed.2019.06.005 |
Keywords | Hypertrophic cardiomyopathy; Disease modeling; HCM mechanisms |
Public URL | https://nottingham-repository.worktribe.com/output/2272833 |
Publisher URL | https://www.sciencedirect.com/science/article/pii/S1471491419301674?via%3Dihub |
Contract Date | Jul 5, 2019 |
Files
Mosqueira Et Al Manuscript TIMM REVISED FINAL2
(3.9 Mb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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