A heritable subset of the core rumen microbiome dictates dairy cow productivity and emissions

Wallace, R. John; Sasson, Goor; Garnsworthy, Philip C.; Tapio, Ilma; Gregson, Emma; Bani, Paolo; Huhtanen, Pekka; Bayat, Ali R.; Strozzi, Francesco; Biscarini, Filippo; Snelling, Timothy J.; Saunders, Neil; Potterton, Sarah L.; Craigon, James; Minuti, Andrea; Trevisi, Erminio; Callegari, Maria L.; Cappelli, Fiorenzo Piccioli; Cabezas-Garcia, Edward H.; Vilkki, Johanna; Pinares-Patino, Cesar; Fliegerová, Kateřina O.; Mrázek, Jakub; Sechovcová, Hana; Kopečný, Jan; Bonin, Aurélie; Boyer, Frédéric; Taberlet, Pierre; Kokou, Fotini; Halperin, Eran; Williams, John L.; Shingfield, Kevin J.; Mizrahi, Itzhak

Abstract

A 1000-cow study across four European countries was undertaken to understand to what extent ruminant microbiomes can be controlled by the host animal and to identify characteristics of the host rumen microbiome axis that determine productivity and methane emissions. A core rumen microbiome, phylogenetically linked and with a preserved hierarchical structure, was identified. A 39-member subset of the core formed hubs in co-occurrence networks linking microbiome structure to host genetics and phenotype (methane emissions, rumen and blood metabolites, and milk production efficiency). These phenotypes can be predicted from the core microbiome using machine learning algorithms. The heritable core microbes, therefore, present primary targets for rumen manipulation
toward sustainable and environmentally friendly agriculture.

Citation

Wallace, R. J., Sasson, G., Garnsworthy, P. C., Tapio, I., Gregson, E., Bani, P., Huhtanen, P., Bayat, A. R., Strozzi, F., Biscarini, F., Snelling, T. J., Saunders, N., Potterton, S. L., Craigon, J., Minuti, A., Trevisi, E., Callegari, M. L., Cappelli, F. P., Cabezas-Garcia, E. H., Vilkki, J., …Mizrahi, I. (2019). A heritable subset of the core rumen microbiome dictates dairy cow productivity and emissions. Science Advances, 5(7), Article eaav8391. https://doi.org/10.1126/sciadv.aav8391

• Journal Article Type: Article
• Acceptance Date: May 30, 2019
• Online Publication Date: Jul 3, 2019
• Publication Date: Jul 3, 2019
• Deposit Date: Jul 4, 2019
• Publicly Available Date: Jul 11, 2019
• Journal: Science Advances
• Electronic ISSN: 2375-2548
• Publisher: American Association for the Advancement of Science
• Peer Reviewed: Peer Reviewed
• Volume: 5
• Issue: 7
• Article Number: eaav8391
• DOI: https://doi.org/10.1126/sciadv.aav8391
• Public URL: https://nottingham-repository.worktribe.com/output/2270297
• Publisher URL: https://advances.sciencemag.org/content/5/7/eaav8391
• Contract Date: Jul 4, 2019