Quantitative assessment of renal structural and functional changes in chronic kidney disease using multi-parametric magnetic resonance imaging

Buchanan, Charlotte E.; Mahmoud, Huda; Cox, Eleanor F.; McCulloch, Thomas; Prestwich, Benjamin L.; Taal, Maarten W.; Selby, Nicholas M.; Francis, Susan T.

Abstract

BACKGROUND:
Multi-parametric magnetic resonance imaging (MRI) provides the potential for a more comprehensive non-invasive assessment of organ structure and function than individual MRI measures, but has not previously been comprehensively evaluated in chronic kidney disease (CKD).

METHODS:
We performed multi-parametric renal MRI in persons with CKD (n = 22, 61 ± 24 years) who had a renal biopsy and measured glomerular filtration rate (mGFR), and matched healthy volunteers (HV) (n = 22, 61 ± 25 years). Longitudinal relaxation time (T1), diffusion-weighted imaging, renal blood flow (phase contrast MRI), cortical perfusion (arterial spin labelling) and blood-oxygen-level-dependent relaxation rate (R2*) were evaluated.

RESULTS:
MRI evidenced excellent reproducibility in CKD (coefficient of variation 

Citation

Buchanan, C. E., Mahmoud, H., Cox, E. F., McCulloch, T., Prestwich, B. L., Taal, M. W., …Francis, S. T. (2020). Quantitative assessment of renal structural and functional changes in chronic kidney disease using multi-parametric magnetic resonance imaging. Nephrology Dialysis Transplantation, 35(6), 955-964. https://doi.org/10.1093/ndt/gfz129

• Journal Article Type: Article
• Acceptance Date: May 13, 2019
• Online Publication Date: Jun 29, 2019
• Publication Date: Jun 1, 2020
• Deposit Date: Jul 2, 2019
• Publicly Available Date: Jul 17, 2019
• Journal: Nephrology Dialysis Transplantation
• Print ISSN: 0931-0509
• Electronic ISSN: 1460-2385
• Publisher: Oxford University Press
• Peer Reviewed: Peer Reviewed
• Volume: 35
• Issue: 6
• Pages: 955-964
• DOI: https://doi.org/10.1093/ndt/gfz129
• Keywords: Nephrology; Transplantation
• Public URL: https://nottingham-repository.worktribe.com/output/2258080
• Publisher URL: https://academic.oup.com/ndt/article/35/6/955/5525254
• Contract Date: Jul 17, 2019