Ubiquitin-Mediated Control of ETS Transcription Factors: Roles in Cancer and Development

Ducker, Charles; Shaw, Peter E.

Abstract

Genome expansion, whole genome and gene duplication events during metazoan evolution produced an extensive family of ETS genes whose members express transcription factors with a conserved winged helix-turn-helix DNA-binding domain. Unravelling their biological roles has proved challenging with functional redundancy manifest in overlapping expression patterns, a common consensus DNA-binding motif and responsiveness to mitogen-activated protein kinase signalling. Key determinants of the cellular repertoire of ETS proteins are their stability and turnover, controlled largely by the actions of selective E3 ubiquitin ligases and deubiquitinases. Here we discuss the known relationships between ETS proteins and enzymes that determine their ubiquitin status, their integration with other developmental signal transduction pathways and how suppression of ETS protein ubiquitination contributes to the malignant cell phenotype in multiple cancers.

Citation

Ducker, C., & Shaw, P. E. (2021). Ubiquitin-Mediated Control of ETS Transcription Factors: Roles in Cancer and Development. International Journal of Molecular Sciences, 22(10), Article 5119. https://doi.org/10.3390/ijms22105119

• Journal Article Type: Article
• Acceptance Date: May 7, 2021
• Online Publication Date: May 12, 2021
• Publication Date: May 12, 2021
• Deposit Date: Jun 28, 2023
• Publicly Available Date: Jun 29, 2023
• Journal: International Journal of Molecular Sciences
• Print ISSN: 1661-6596
• Electronic ISSN: 1422-0067
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 22
• Issue: 10
• Article Number: 5119
• DOI: https://doi.org/10.3390/ijms22105119
• Keywords: E3 ligase complex; deubiquitinase; gene fusions; mitogens; phosphorylation; DNA damage
• Public URL: https://nottingham-repository.worktribe.com/output/22399926
• Publisher URL: https://www.mdpi.com/1422-0067/22/10/5119