Increased fasting small bowel water content in untreated coeliac disease and scleroderma as assessed by MRI

Lam, Ching; Sanders, David; Lanyon, Peter; Garsed, Klara; Foley, Stephen; Pritchard, Susan

Abstract

Background and aims: The regular overnight migrating motor complex (MMC) ensures that the normal fasting small bowel water content (SBWC) is minimised. We have applied our recently validated non-invasive magnetic resonance technique to assess SBWC in newly diagnosed coeliac disease (CD), scleroderma (SCD) and irritable bowel syndrome (IBS) conditions, possibly associated with small intestinal bacterial overgrowth (SIBO).
Methods: 20 CD and 15 SCD patients with gastrointestinal symptoms were compared to 20 healthy volunteers (HV) and 26 IBS with diarrhoea (IBS-D) patients as previously reported. All underwent a fasting, magnetic resonance imaging (MRI) scan on a 1.5 T Philips Achieva MRI scanner to assess fasting SBWC and colonic volumes. Stool and symptom diaries were completed for 1 week.
Results: Median (Interquartile range, IQR)
Compared to healthy volunteers, all the patients had significantly increased stool frequency and Bristol stool form score. SBWC was significantly increased in CD 109(53-224) vs. 53(31-98) mL in HV, p

Citation

Lam, C., Sanders, D., Lanyon, P., Garsed, K., Foley, S., & Pritchard, S. (2019). Increased fasting small bowel water content in untreated coeliac disease and scleroderma as assessed by MRI. United European Gastroenterology Journal, 7(10), 1353-1360. https://doi.org/10.1177/2050640619860372

• Journal Article Type: Article
• Acceptance Date: Apr 26, 2019
• Online Publication Date: Jul 21, 2019
• Publication Date: 2019-12
• Deposit Date: Jul 12, 2019
• Publicly Available Date: Jul 15, 2019
• Journal: United European Gastroenterology Journal
• Print ISSN: 2050-6406
• Electronic ISSN: 2050-6414
• Publisher: SAGE Publications
• Peer Reviewed: Peer Reviewed
• Volume: 7
• Issue: 10
• Pages: 1353-1360
• DOI: https://doi.org/10.1177/2050640619860372
• Public URL: https://nottingham-repository.worktribe.com/output/2187962
• Publisher URL: https://journals.sagepub.com/doi/full/10.1177/2050640619860372
• Contract Date: Jul 12, 2019