Gourav Dhiman
Metadherin: A Therapeutic Target in Multiple Cancers
Dhiman, Gourav; Srivastava, Neha; Goyal, Mehendi; Rakha, Emad; Lothion-Roy, Jennifer; Mongan, Nigel P.; Miftakhova, Regina R.; Khaiboullina, Svetlana F.; Rizvanov, Albert A.; Baranwal, Manoj
Authors
Neha Srivastava
Mehendi Goyal
EMAD RAKHA Emad.Rakha@nottingham.ac.uk
Professor of Breast Cancer Pathology
Jennifer Lothion-Roy
NIGEL MONGAN nigel.mongan@nottingham.ac.uk
Professor of Oncology
Regina R. Miftakhova
Svetlana F. Khaiboullina
Albert A. Rizvanov
Manoj Baranwal
Abstract
Altered expression of many genes and proteins is essential for cancer development and progression. Recently, the affected expression of metadherin (MTDH), also known as AEG-1 (Astrocyte Elevated Gene 1) and Lyric, has been implicated in various aspects of cancer progression and metastasis. Elevated expression of MTDH/AEG-1 has been reported in many cancers including breast, prostate, liver, and esophageal cancers, whereas its expression is low or absent in non-malignant tissues. These expression studies suggest that MTDH may represent a potential tumor associated antigen. MTDH also regulates multiple signaling pathways including PI3K/Akt, NF-κB, Wnt/β-catenin, and MAPK which cooperate to promote the tumorigenic and metastatic potential of transformed cells. Several microRNA have also been found to be associated with the increased MTDH expression in different cancers. Increased MTDH levels were linked to the tumor chemoresistance making it an attractive novel therapeutic target. In this review, we summarize data on MTDH function in various cancers.
Citation
Dhiman, G., Srivastava, N., Goyal, M., Rakha, E., Lothion-Roy, J., Mongan, N. P., …Baranwal, M. (2019). Metadherin: A Therapeutic Target in Multiple Cancers. Frontiers in Oncology, 9, Article 349. https://doi.org/10.3389/fonc.2019.00349
Journal Article Type | Article |
---|---|
Acceptance Date | Apr 15, 2019 |
Online Publication Date | May 3, 2019 |
Publication Date | May 3, 2019 |
Deposit Date | Jun 18, 2019 |
Publicly Available Date | Jun 26, 2019 |
Journal | Frontiers in Oncology |
Electronic ISSN | 2234-943X |
Publisher | Frontiers Media |
Peer Reviewed | Peer Reviewed |
Volume | 9 |
Article Number | 349 |
DOI | https://doi.org/10.3389/fonc.2019.00349 |
Keywords | Cancer research, Oncology, Metadherin, Chemoresistance, microRNA, Immunotherapy, Cancer |
Public URL | https://nottingham-repository.worktribe.com/output/2183573 |
Publisher URL | https://www.frontiersin.org/articles/10.3389/fonc.2019.00349/full |
Contract Date | Jun 26, 2019 |
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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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