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Metadherin: A Therapeutic Target in Multiple Cancers

Dhiman, Gourav; Srivastava, Neha; Goyal, Mehendi; Rakha, Emad; Lothion-Roy, Jennifer; Mongan, Nigel P.; Miftakhova, Regina R.; Khaiboullina, Svetlana F.; Rizvanov, Albert A.; Baranwal, Manoj

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Authors

Gourav Dhiman

Neha Srivastava

Mehendi Goyal

Jennifer Lothion-Roy

Regina R. Miftakhova

Svetlana F. Khaiboullina

Albert A. Rizvanov

Manoj Baranwal



Abstract

Altered expression of many genes and proteins is essential for cancer development and progression. Recently, the affected expression of metadherin (MTDH), also known as AEG-1 (Astrocyte Elevated Gene 1) and Lyric, has been implicated in various aspects of cancer progression and metastasis. Elevated expression of MTDH/AEG-1 has been reported in many cancers including breast, prostate, liver, and esophageal cancers, whereas its expression is low or absent in non-malignant tissues. These expression studies suggest that MTDH may represent a potential tumor associated antigen. MTDH also regulates multiple signaling pathways including PI3K/Akt, NF-κB, Wnt/β-catenin, and MAPK which cooperate to promote the tumorigenic and metastatic potential of transformed cells. Several microRNA have also been found to be associated with the increased MTDH expression in different cancers. Increased MTDH levels were linked to the tumor chemoresistance making it an attractive novel therapeutic target. In this review, we summarize data on MTDH function in various cancers.

Citation

Dhiman, G., Srivastava, N., Goyal, M., Rakha, E., Lothion-Roy, J., Mongan, N. P., Miftakhova, R. R., Khaiboullina, S. F., Rizvanov, A. A., & Baranwal, M. (2019). Metadherin: A Therapeutic Target in Multiple Cancers. Frontiers in Oncology, 9, Article 349. https://doi.org/10.3389/fonc.2019.00349

Journal Article Type Article
Acceptance Date Apr 15, 2019
Online Publication Date May 3, 2019
Publication Date May 3, 2019
Deposit Date Jun 18, 2019
Publicly Available Date Jun 26, 2019
Journal Frontiers in Oncology
Electronic ISSN 2234-943X
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 9
Article Number 349
DOI https://doi.org/10.3389/fonc.2019.00349
Keywords Cancer research, Oncology, Metadherin, Chemoresistance, microRNA, Immunotherapy, Cancer
Public URL https://nottingham-repository.worktribe.com/output/2183573
Publisher URL https://www.frontiersin.org/articles/10.3389/fonc.2019.00349/full
Contract Date Jun 26, 2019

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