Ms TOSHANA FOSTER TOSHANA.FOSTER@NOTTINGHAM.AC.UK
Associate Professor
Inhibiting the ins and outs of HIV replication: cell-intrinsic antiretroviral restrictions at the plasma membrane
Foster, Toshana L.; Pickering, Suzanne; Neil, Stuart J. D.
Authors
Suzanne Pickering
Stuart J. D. Neil
Abstract
© 2018 Foster, Pickering and Neil. Like all viruses, human immunodeficiency viruses (HIVs) and their primate lentivirus relatives must enter cells in order to replicate and, once produced, new virions need to exit to spread to new targets. These processes require the virus to cross the plasma membrane of the cell twice: once via fusion mediated by the envelope glycoprotein to deliver the viral core into the cytosol; and secondly by ESCRT-mediated scission of budding virions during release. This physical barrier thus presents a perfect location for host antiviral restrictions that target enveloped viruses in general. In this review we will examine the current understanding of innate host antiviral defences that inhibit these essential replicative steps of primate lentiviruses associated with the plasma membrane, the mechanism by which these viruses have adapted to evade such defences, and the role that this virus/host battleground plays in the transmission and pathogenesis of HIV/AIDS.
Citation
Foster, T. L., Pickering, S., & Neil, S. J. D. (2018). Inhibiting the ins and outs of HIV replication: cell-intrinsic antiretroviral restrictions at the plasma membrane. Frontiers in Immunology, 8, Article 1853. https://doi.org/10.3389/fimmu.2017.01853
| Journal Article Type | Article |
|---|---|
| Acceptance Date | Dec 7, 2017 |
| Online Publication Date | Jan 4, 2018 |
| Publication Date | Jan 4, 2018 |
| Deposit Date | Mar 21, 2019 |
| Publicly Available Date | Mar 21, 2019 |
| Journal | Frontiers in Immunology |
| Electronic ISSN | 1664-3224 |
| Publisher | Frontiers Media |
| Peer Reviewed | Peer Reviewed |
| Volume | 8 |
| Article Number | 1853 |
| DOI | https://doi.org/10.3389/fimmu.2017.01853 |
| Public URL | https://nottingham-repository.worktribe.com/output/1672405 |
| Publisher URL | https://www.frontiersin.org/articles/10.3389/fimmu.2017.01853/full |
| Contract Date | Mar 21, 2019 |
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Inhibiting the Ins and Outs of HIV Replication: Cell-Intrinsic Antiretroviral Restrictions at the Plasma Membrane
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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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