Dr KIERAN AYLING Kieran.Ayling@nottingham.ac.uk
SENIOR RESEARCH FELLOW
Optimizing mood prior to influenza vaccination in older adults: A three-arm randomized controlled trial
Ayling, Kieran; Brown, Michaela; Carlisle, Sophie; Bennett, Robert; Buchanan, Heather; Dumbleton, Jennifer; Hawkey, Christopher; Hoschler, Katja; Jack, Ruth H; Nguyen-Van-Tam, Jonathan; Royal, Simon; Turner, David; Zambon, Maria; Fairclough, Lucy; Vedhara, Kavita
Authors
Michaela Brown
Sophie Carlisle
Robert Bennett
Dr Heather Buchanan heather.buchanan@nottingham.ac.uk
ASSOCIATE PROFESSOR
Jennifer Dumbleton
Christopher Hawkey
Katja Hoschler
Dr RUTH JACK Ruth.Jack@nottingham.ac.uk
SENIOR RESEARCH FELLOW
Jonathan Nguyen-Van-Tam
Simon Royal
Dr DAVID TURNER david.turner@nottingham.ac.uk
CLINICAL ASSOCIATE PROFESSOR
Maria Zambon
Professor Lucy Fairclough LUCY.FAIRCLOUGH@NOTTINGHAM.AC.UK
PROFESSOR OF IMMUNOLOGY
Kavita Vedhara
Abstract
Objective: This trial explored the psychological and immunological effects of two brief interventions, targeting improving positive mood, administered to older adults immediately prior to influenza vaccination. The primary aim was to examine whether the interventions resulted in greater positive mood compared to usual care, and if so, which was superior. Secondary outcomes included antibody responses to vaccination and feasibility of collecting clinical outcome data (e.g., respiratory infections). Method: Six hundred and fifty-four older adults (65–85 years) participated in a three-arm, parallel, randomized controlled trial between September 2019 and May 2020. Immediately prior to receiving an adjuvanted trivalent influenza vaccine (Fluad, Seqirus UK Ltd), participants viewed one of two brief (15-min) video-based positive mood interventions (one fixed content, one allowing participant choice) or received usual care. State affect was measured immediately prior to, and following, intervention exposure or usual care. Antibody responses were measured prevaccination and 4 weeks postvaccination. Clinical outcomes were extracted from primary care records for 6 months following vaccination. Results: Both interventions were equally effective at improving mood prior to vaccination compared to usual care. Antibody responses were highly robust with postvaccination seroprotection rates of >88% observed for all vaccine strains. Antibody responses did not significantly differ between groups. Clinical outcome data were feasible to collect. Conclusions: Brief psychological interventions can improve mood prior to vaccination. However, altering antibody responses to highly immunogenic adjuvanted vaccines may require more targeted or prolonged interventions. The provision of choice did not notably enhance the interventions impact on mood or antibody outcomes.
Citation
Ayling, K., Brown, M., Carlisle, S., Bennett, R., Buchanan, H., Dumbleton, J., Hawkey, C., Hoschler, K., Jack, R. H., Nguyen-Van-Tam, J., Royal, S., Turner, D., Zambon, M., Fairclough, L., & Vedhara, K. (2023). Optimizing mood prior to influenza vaccination in older adults: A three-arm randomized controlled trial. Health Psychology, 43(2), 77-88. https://doi.org/10.1037/hea0001267
Journal Article Type | Article |
---|---|
Acceptance Date | Dec 5, 2022 |
Online Publication Date | Dec 7, 2023 |
Publication Date | Dec 7, 2023 |
Deposit Date | Dec 7, 2022 |
Publicly Available Date | Dec 7, 2023 |
Journal | Health Psychology |
Print ISSN | 0278-6133 |
Electronic ISSN | 1930-7810 |
Publisher | American Psychological Association |
Peer Reviewed | Peer Reviewed |
Volume | 43 |
Issue | 2 |
Pages | 77-88 |
DOI | https://doi.org/10.1037/hea0001267 |
Public URL | https://nottingham-repository.worktribe.com/output/14596085 |
Publisher URL | https://psycnet.apa.org/fulltext/2024-33034-001.html |
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Ayling Health Psychology 2023
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Licence
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Publisher Licence URL
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