Variation in lung function and alterations in cardiac 1 structure and function: analysis of the UK Biobank 2 cardiovascular magnetic resonance imaging substudy

Thomson, Ross J.; Aung, Nay; Sanghvi, Mihir M.; Paiva, José Miguel; Lee, Aaron M; Fung, Kenneth; Pfeffer, Paul E.; Mackay, Alexander J.; Mckeever, Tricia M.; Lukaschuk, Elena 5; Carapella, Valentina; Kim, Young Jin; Bolton, Charlotte E.; Piechnik, Stefan K; Neubauer, Stefan; Petersen, Steffen E.

Abstract

Background

Reduced lung function is common and associated with increased cardiovascular morbidity and mortality, even in asymptomatic individuals without diagnosed respiratory disease. Previous studies have identified relationships between lung function and cardiovascular structure in individuals with pulmonary disease, but the relationships in those free from diagnosed cardiorespiratory disease have not been fully explored.


Methods

UK Biobank is a prospective cohort study of community participants in the United Kingdom. Individuals self-reported demographics and co-morbidities, and a subset underwent cardiovascular magnetic resonance (CMR) imaging and spirometry. CMR images were analysed to derive ventricular volumes and mass. The relationships between CMR-derived measures and spirometry and age were modelled with multivariable linear regression, taking account of the effects of possible confounders.


Results

Data were available for 4,975 individuals, and after exclusion of those with pre-existing cardiorespiratory disease and unacceptable spirometry, 1,406 were included in the analyses. In fully-adjusted multivariable linear models lower FEV1 and FVC were associated with smaller left ventricular end-diastolic (−5.21ml per standard deviation (SD) change in FEV1, −5.69ml per SD change in FVC), end-systolic (−2.34ml, −2.56ml) and stroke volumes (−2.85ml, −3.11ml); right ventricular end-diastolic (−5.62ml, −5.84ml), end-systolic (−2.47ml, −2.46ml) and stroke volumes (−3.13ml, −3.36ml); and with lower left ventricular mass (−2.29g, −2.46g). Changes of comparable magnitude and direction were observed per decade increase in age.


Conclusions

This study shows that reduced FEV1 and FVC are associated with smaller ventricular volumes and reduced ventricular mass. The changes seen per standard deviation change in FEV1 and FVC are comparable to one decade of ageing.

Citation

Thomson, R. J., Aung, N., Sanghvi, M. M., Paiva, J. M., Lee, A. M., Fung, K., Pfeffer, P. E., Mackay, A. J., Mckeever, T. M., Lukaschuk, E. 5., Carapella, V., Kim, Y. J., Bolton, C. E., Piechnik, S. K., Neubauer, S., & Petersen, S. E. (2018). Variation in lung function and alterations in cardiac 1 structure and function: analysis of the UK Biobank 2 cardiovascular magnetic resonance imaging substudy. PLoS ONE, 13(3), Article e0194434. https://doi.org/10.1371/journal.pone.0194434

• Journal Article Type: Article
• Acceptance Date: Mar 3, 2018
• Online Publication Date: Mar 20, 2018
• Publication Date: Mar 20, 2018
• Deposit Date: Nov 23, 2018
• Publicly Available Date: Nov 26, 2018
• Journal: PLoS ONE
• Electronic ISSN: 1932-6203
• Publisher: Public Library of Science
• Peer Reviewed: Peer Reviewed
• Volume: 13
• Issue: 3
• Article Number: e0194434
• DOI: https://doi.org/10.1371/journal.pone.0194434
• Public URL: https://nottingham-repository.worktribe.com/output/1305568
• Publisher URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194434
• Contract Date: Nov 26, 2018