Patrick P. Ng
B-cell receptors expressed by lymphomas of hepatitis C virus (HCV)-infected patients rarely react with the viral proteins
Ng, Patrick P.; BALL, JONATHAN; Kuo, Chiung-Chi; Wang, Stanley; Einav, Shirit; Arcaini, Luca; Paulli, Marco; Portlock, Carol S.; Marcotrigiano, Joseph; Tarr, Alexander; Levy, Ronald; Levy, Shoshana
Authors
JONATHAN BALL jonathan.ball@nottingham.ac.uk
Professor of Molecular Virology
Chiung-Chi Kuo
Stanley Wang
Shirit Einav
Luca Arcaini
Marco Paulli
Carol S. Portlock
Joseph Marcotrigiano
ALEXANDER TARR alex.tarr@nottingham.ac.uk
Associate Professor
Ronald Levy
Shoshana Levy
Abstract
Chronic hepatitis C virus (HCV) infection has been implicated in the induction and maintenance of B-cell lymphomas. The strongest evidence for this derives from clinical observations of tumor regressions upon antiviral treatments. Here we used multiple methods to test the hypothesis that the expansion of HCV-specific B cells gives rise to lymphomas. We obtained lymphoma tissues from HCV-infected lymphoma patients, including some that later regressed upon antiviral treatments. We expressed the lymphoma B-cell receptors as soluble immunoglobulin Gs and membrane IgMs, and analyzed their reactivity with HCV proteins and with HCV virions. We confirmed previous reports that HCV-associated lymphomas use a restricted immunoglobulin variable region gene repertoire. However, we found no evidence for their binding to the HCV antigens. We conclude that most lymphomas of HCV-infected patients do not arise from B cells aimed at eliminating the virus.
Journal Article Type | Article |
---|---|
Acceptance Date | Dec 29, 2013 |
Online Publication Date | Mar 6, 2014 |
Publication Date | Jan 21, 2014 |
Deposit Date | Aug 10, 2017 |
Journal | Blood |
Print ISSN | 0006-4971 |
Publisher | American Society of Hematology |
Peer Reviewed | Peer Reviewed |
Volume | 123 |
Issue | 10 |
Pages | 1512–1515 |
DOI | https://doi.org/10.1182/blood-2013-10-532895 |
Public URL | https://nottingham-repository.worktribe.com/output/1114915 |
Publisher URL | https://ashpublications.org/blood/article/123/10/1512/32391/B-cell-receptors-expressed-by-lymphomas-of |
You might also like
Dramatic potentiation of the antiviral activity of HIV antibodies by cholesterol conjugation
(2014)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: discovery-access-systems@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search