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The Harmonizing Outcome Measures for Eczema (HOME) roadmap: a methodological framework to develop core sets of outcome measurements in dermatology

Schmitt, Jochen; Apfelbacher, Christian; Spuls, Phyllis I.; Thomas, Kim S.; Simpson, Eric L.; Furue, Masutaka; Chalmers, Joanne; Williams, Hywel C.

Authors

Jochen Schmitt

Christian Apfelbacher

Phyllis I. Spuls

Eric L. Simpson

Masutaka Furue

Joanne Chalmers

Profile image of HYWEL WILLIAMS

HYWEL WILLIAMS HYWEL.WILLIAMS@NOTTINGHAM.AC.UK
Professor of Dermato-Epidemiology



Abstract

Core outcome sets (COSs) are consensus-derived minimum sets of outcomes to be assessed in a specific situation. COSs are being increasingly developed to limit outcome-reporting bias, allow comparisons across trials, and strengthen clinical decision making. Despite the increasing interest in outcomes research, methods to develop COSs have not yet been standardized. The aim of this paper is to present the Harmonizing Outcomes Measures for Eczema (HOME) roadmap for the development and implementation of COSs, which was developed on the basis of our experience in the standardization of outcome measurements for atopic eczema. Following the establishment of a panel representing all relevant stakeholders and a research team experienced in outcomes research, the scope and setting of the core set should be defined. The next steps are the definition of a core set of outcome domains such as symptoms or quality of life, followed by the identification or development and validation of appropriate outcome measurement instruments to measure these core domains. Finally, the consented COS needs to be disseminated, implemented, and reviewed. We believe that the HOME roadmap is a useful methodological framework to develop COSs in dermatology, with the ultimate goal of better decision making and promoting patient-centered health care.

Journal Article Type Article
Acceptance Date Jul 14, 2014
Online Publication Date Dec 8, 2015
Publication Date 2015-01
Deposit Date Sep 17, 2018
Journal Journal of Investigative Dermatology
Print ISSN 0022-202X
Electronic ISSN 1523-1747
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 135
Issue 1
Pages 24-30
DOI https://doi.org/10.1038/jid.2014.320
Public URL https://nottingham-repository.worktribe.com/output/1099930
PMID 25186228
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