Changes in electrophysiological markers of cognitive control after administration of galantamine

Robson, Siân E.; Gascoyne, Lauren E.; Mullinger, Karen J.; Robson, Sian; Kumar, Jyothika; O'Neill, George C.; Palaniyappan, Lena; Morris, Peter G.; Liddle, Elizabeth B.; Brookes, Matthew J.; Liddle, Peter F.

Abstract

© 2018 The healthy brain is able to maintain a stable balance between bottom-up sensory processing and top-down cognitive control. The neurotransmitter acetylcholine plays a substantial role in this. Disruption of this balance could contribute to symptoms occurring in psychosis, including subtle disruption of motor control and aberrant appropriation of salience to external stimuli; however the pathological mechanisms are poorly understood. On account of the role beta oscillations play in mediating cognitive control, investigation of beta oscillations is potentially informative about such mechanisms. Here, we used magnetoencephalography to investigate the effect of the acetylcholinesterase-inhibitor, galantamine, on beta oscillations within the sensorimotor region during both a sensorimotor task and a relevance–modulation task in healthy participants, employing a double blind randomized placebo controlled cross-over design. In the galantamine condition, we found a significant reduction in the post-movement beta rebound in the case of executed movements and also in a planned but not executed movement. In the latter case, the effect was significantly greater following task-relevant compared with irrelevant stimuli. The results suggest that the action of galantamine reduces the influence of top-down cognitive processing relative to bottom-up perceptual processing in a manner resembling changes previously reported in schizophrenia.

Citation

Robson, S. E., Gascoyne, L. E., Mullinger, K. J., Robson, S., Kumar, J., O'Neill, G. C., Palaniyappan, L., Morris, P. G., Liddle, E. B., Brookes, M. J., & Liddle, P. F. (2018). Changes in electrophysiological markers of cognitive control after administration of galantamine. NeuroImage: Clinical, 20, 228-235. https://doi.org/10.1016/j.nicl.2018.07.019

• Journal Article Type: Article
• Acceptance Date: Jul 21, 2018
• Online Publication Date: Jul 23, 2018
• Publication Date: Oct 31, 2018
• Deposit Date: Oct 16, 2018
• Publicly Available Date: Oct 16, 2018
• Journal: NeuroImage: Clinical
• Electronic ISSN: 2213-1582
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 20
• Pages: 228-235
• DOI: https://doi.org/10.1016/j.nicl.2018.07.019
• Keywords: Cognitive Neuroscience; Radiology Nuclear Medicine and imaging; Neurology; Clinical Neurology
• Public URL: https://nottingham-repository.worktribe.com/output/1067356
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S2213158218302316
• Additional Information: This article is maintained by: Elsevier; Article Title: Changes in electrophysiological markers of cognitive control after administration of galantamine; Journal Title: NeuroImage: Clinical; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.nicl.2018.07.019; Content Type: article; Copyright: © 2018 The Authors. Published by Elsevier Inc.
• Contract Date: Oct 16, 2018