Omer Aras
An in-vivo pilot study into the effects of FDG-mNP in cancer in mice
Aras, Omer; Pearce, Gillian; Watkins, Adam J.; Nurili, Fuad; Medine, Emin Ilker; Guldu, Ozge Kozgus; Tekin, Volkan; Wong, Julian; Ma, Xianghong; Ting, Richard; Unak, Perihan; Akin, Oguz
Authors
Gillian Pearce
ADAM WATKINS Adam.Watkins@nottingham.ac.uk
Associate Professor
Fuad Nurili
Emin Ilker Medine
Ozge Kozgus Guldu
Volkan Tekin
Julian Wong
Xianghong Ma
Richard Ting
Perihan Unak
Oguz Akin
Contributors
Bing Xu
Editor
Abstract
PURPOSE:
Previously, fluorodeoxy glucose conjugated magnetite nanoparticles (FDG-mNPs) injected into cancer cells in conjunction with the application of magnetic hyperthermia have shown promise in new FDG-mNPs applications. The aim of this study was to determine potential toxic or unwanted effects involving both tumour cells and normal tissue in other organs when FDG-mNPs are administered intravenously or intratumourally in mice.
MATERIALS AND METHODS:
FDG-mNPs were synthesized. A group of six prostate-tumour bearing mice were injected with 23.42 mg/ml FDG-mNPs (intravenous injection, n = 3; intratumoural injection into the prostate tumour, n = 3). Mice were euthanized and histological sampling of tissue was conducted for the prostate tumour, as well as for lungs, lymph nodes, liver, kidneys, spleen, and brain, at 1 hour (n = 2) and 7 days (n = 4) post-injection. A second group of two normal (non-cancerous) mice received the same injection intravenously into the tail vein and were euthanised at 3 and 6 months post-injection, respectively, to investigate if FDG-mNPs remained in organs at those time points.
RESULTS:
In prostate-tumour bearing mice, FDG-mNPs concentrated in the prostate tumour, while relatively small amounts were found in the organs of other tissues, particularly the spleen and the liver; FDG-mNP concentrations decreased over time in all tissues. In normal mice, no detrimental effects were found in either mouse at 3 or 6 months.
CONCLUSION:
Intravenous or intratumoural FDG-mNPs can be safely administered for effective cancer cell destruction. Further research on the clinical utility of FDG-mNPs will be conducted by applying hyperthermia in conjunction with FDG-mNPs in mice.
Citation
Aras, O., Pearce, G., Watkins, A. J., Nurili, F., Medine, E. I., Guldu, O. K., …Akin, O. (2018). An in-vivo pilot study into the effects of FDG-mNP in cancer in mice. PLoS ONE, 13(8), Article e0202482. https://doi.org/10.1371/journal.pone.0202482
Journal Article Type | Article |
---|---|
Acceptance Date | Aug 10, 2018 |
Online Publication Date | Aug 20, 2018 |
Publication Date | Aug 21, 2018 |
Deposit Date | Aug 21, 2018 |
Publicly Available Date | Aug 21, 2018 |
Journal | PLOS ONE |
Publisher | Public Library of Science |
Peer Reviewed | Peer Reviewed |
Volume | 13 |
Issue | 8 |
Article Number | e0202482 |
DOI | https://doi.org/10.1371/journal.pone.0202482 |
Keywords | General Biochemistry, Genetics and Molecular Biology; General Agricultural and Biological Sciences; General Medicine |
Public URL | https://nottingham-repository.worktribe.com/output/1040923 |
Publisher URL | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202482 |
Contract Date | Aug 21, 2018 |
Files
journal.pone.0202482
(23.4 Mb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/publicdomain
You might also like
Maternal nutrition modifies trophoblast giant cell phenotype and fetal growth in mice
(2015)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: discovery-access-systems@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search