Outputs (633)

Improving lung health in low-income and middle-income countries: from challenges to solutions (2021)
Journal Article
Meghji, J., Mortimer, K., Agusti, A., Allwood, B. W., Asher, I., Bateman, E. D., Bissell, K., Bolton, C. E., Bush, A., Celli, B., Chiang, C.-Y., Cruz, A. A., Dinh-Xuan, A.-T., El Sony, A., Fong, K. M., Fujiwara, P. I., Gaga, M., Garcia-Marcos, L., Halpin, D. M. G., Hurst, J. R., …Marks, G. B. (2021). Improving lung health in low-income and middle-income countries: from challenges to solutions. Lancet, 397(10277), 928-940. https://doi.org/10.1016/S0140-6736%2821%2900458-X

Low-income and middle-income countries (LMICs) bear a disproportionately high burden of the global morbidity and mortality caused by chronic respiratory diseases (CRDs), including asthma, chronic obstructive pulmonary disease, bronchiectasis, and pos... Read More about Improving lung health in low-income and middle-income countries: from challenges to solutions.

Assessment, endoscopy, and treatment in patients with acute severe ulcerative colitis during the COVID-19 pandemic (PROTECT-ASUC): a multicentre, observational, case-control study (2021)
Journal Article
Sebastian, S., Walker, G. J., Kennedy, N. A., Conley, T. E., Patel, K. V., Subramanian, S., Kent, A. J., Segal, J. P., Brookes, M. J., Bhala, N., Gonzalez, H. A., Hicks, L. C., Mehta, S. J., Lamb, C. A., Abdale, S., Abbasi, A., Abusrewil, A., Aghimien, P., Ahmed, S., Ali, A., …Zafar, M. (2021). Assessment, endoscopy, and treatment in patients with acute severe ulcerative colitis during the COVID-19 pandemic (PROTECT-ASUC): a multicentre, observational, case-control study. The Lancet Gastroenterology & Hepatology, 6(4), 271-281. https://doi.org/10.1016/s2468-1253%2821%2900016-9

Background
There is a paucity of evidence to support safe and effective management of patients with acute severe ulcerative colitis during the COVID-19 pandemic. We sought to identify alterations to established conventional evidence-based management... Read More about Assessment, endoscopy, and treatment in patients with acute severe ulcerative colitis during the COVID-19 pandemic (PROTECT-ASUC): a multicentre, observational, case-control study.

MATRix–RICE therapy and autologous haematopoietic stem-cell transplantation in diffuse large B-cell lymphoma with secondary CNS involvement (MARIETTA): an international, single-arm, phase 2 trial (2021)
Journal Article
Ferreri, A. J. M., Doorduijn, J. K., Re, A., Cabras, M. G., Smith, J., Ilariucci, F., Luppi, M., Calimeri, T., Cattaneo, C., Khwaja, J., Botto, B., Cellini, C., Nassi, L., Linton, K., McKay, P., Olivieri, J., Patti, C., Re, F., Fanni, A., Singh, V., …International Extranodal Lymphoma Study Group (IELSG), I. E. L. S. G. (. (2021). MATRix–RICE therapy and autologous haematopoietic stem-cell transplantation in diffuse large B-cell lymphoma with secondary CNS involvement (MARIETTA): an international, single-arm, phase 2 trial. Lancet Haematology, 8(2), e110-e121. https://doi.org/10.1016/S2352-3026%2820%2930366-5

Background: Secondary CNS lymphoma is a rare but potentially lethal event in patients with diffuse large B-cell lymphoma. We aimed to assess the activity and safety of an intensive, CNS-directed chemoimmunotherapy consolidated by autologous haematopo... Read More about MATRix–RICE therapy and autologous haematopoietic stem-cell transplantation in diffuse large B-cell lymphoma with secondary CNS involvement (MARIETTA): an international, single-arm, phase 2 trial.

A systematic review and meta-analysis of Anakinra, Sarilumab, Siltuximab and Tocilizumab for Covid-19 (2021)
Preprint / Working Paper
Khan, F., Fabbri, L., Stewart, I., Robinson A., K., Smyth, A. R., & Jenkins, G. A systematic review and meta-analysis of Anakinra, Sarilumab, Siltuximab and Tocilizumab for Covid-19

Background There is accumulating evidence for an overly activated immune response in severe Covid-19, with several studies exploring the therapeutic role of immunomodulation. Through systematic review and meta-analysis, we assess the effectiveness of... Read More about A systematic review and meta-analysis of Anakinra, Sarilumab, Siltuximab and Tocilizumab for Covid-19.

A phase 1/2 study of the combination of acalabrutinib and vistusertib in patients with relapsed/refractory B-cell malignancies (2021)
Journal Article
Collins, G. P., Clevenger, T. N., Burke, K. A., Yang, B., MacDonald, A., Cunningham, D., Fox, C. P., Goy, A., Gribben, J., Nowakowski, G. S., Roschewski, M., Vose, J. M., Vallurupalli, A., Cheung, J., Raymond, A., Nuttall, B., Stetson, D., Dougherty, B. A., Schalkwijk, S., Carnevalli, L. S., …Flinn, I. (2021). A phase 1/2 study of the combination of acalabrutinib and vistusertib in patients with relapsed/refractory B-cell malignancies. Leukemia & Lymphoma, 62(11), 2625-2636. https://doi.org/10.1080/10428194.2021.1938027

In a phase 1b study of acalabrutinib (a covalent Bruton tyrosine kinase (BTK) inhibitor) in combination with vistusertib (a dual mTORC1/2 inhibitor) in patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL), multiple ascending doses... Read More about A phase 1/2 study of the combination of acalabrutinib and vistusertib in patients with relapsed/refractory B-cell malignancies.

ERS international congress 2020: Highlights from the paediatric assembly (2021)
Journal Article
Ardura-Garcia, C., Cuevas-Ocaña, S., Freitag, N., Kampouras, A., King, J. A., Kouis, P., Mensink-Bout, S. M., Whitehouse, A. L., Williams, E., Dassios, T., Duijts, L., Ersu, R. H., Gaillard, E. A., Horsley, A. R., Proesmans, M., Rottier, R., Schramm, D., Moeller, A., & Pijnenburg, M. W. (2021). ERS international congress 2020: Highlights from the paediatric assembly. ERJ Open Research, 7(1), Article 00893-2020. https://doi.org/10.1183/23120541.00893-2020

In this review, the Paediatric Assembly of the European Respiratory Society (ERS) presents a summary of the highlights and most relevant findings in the field of paediatric respiratory medicine presented at the virtual ERS International Congress 2020... Read More about ERS international congress 2020: Highlights from the paediatric assembly.

RAD50 deficiency is a predictor of platinum sensitivity in sporadic epithelial ovarian cancers (2020)
Journal Article
Alblihy, A., Alabdullah, M. L., Toss, M. S., Algethami, M., Mongan, N. P., Rakha, E. A., & Madhusudan, S. (2020). RAD50 deficiency is a predictor of platinum sensitivity in sporadic epithelial ovarian cancers. Molecular Biomedicine, 1(1), Article 19. https://doi.org/10.1186/s43556-020-00023-y

Intrinsic or acquired resistance seriously limits the use of platinating agents in advanced epithelial ovarian cancers. Increased DNA repair capacity is a key route to platinum resistance. RAD50 is a critical component of the MRN complex, a ‘first re... Read More about RAD50 deficiency is a predictor of platinum sensitivity in sporadic epithelial ovarian cancers.

A phase II randomized clinical trial of the safety and efficacy of intravenous umbilical cord blood infusion for treatment of children with autism spectrum disorder (2020)
Journal Article
Nguyen, L. T., Nguyen, P. H., & Hoang, D. M. (2021). A phase II randomized clinical trial of the safety and efficacy of intravenous umbilical cord blood infusion for treatment of children with autism spectrum disorder. Journal of Pediatrics, 230, 271-272. https://doi.org/10.1016/j.jpeds.2020.11.063

Standardized xeno- and serum-free culture platform enables large-scale expansion of high-quality mesenchymal stem/stromal cells from perinatal and adult tissue sources (2020)
Journal Article
Hoang, V. T., Trinh, Q. M., Phuong, D. T. M., Bui, H. T. H., Hang, L. M., Ngan, N. T. H., Anh, N. T. T., Nhi, P. Y., Nhung, T. T. H., Lien, H. T., Nguyen, T. D., Thanh, L. N., & Hoang, D. M. (2021). Standardized xeno- and serum-free culture platform enables large-scale expansion of high-quality mesenchymal stem/stromal cells from perinatal and adult tissue sources. Cytotherapy, 23(1), 88-99. https://doi.org/10.1016/j.jcyt.2020.09.004

Background aims
Mesenchymal stem/stromal cells (MSCs) are of interest for the treatment of graft-versus-host disease, autoimmune diseases, osteoarthritis and neurological and cardiovascular diseases. Increasing numbers of clinical trials emphasize t... Read More about Standardized xeno- and serum-free culture platform enables large-scale expansion of high-quality mesenchymal stem/stromal cells from perinatal and adult tissue sources.

Allogeneic Administration of Human Umbilical Cord-derived Mesenchymal Stem/Stromal Cells for Bronchopulmonary Dysplasia: Preliminary Outcomes in Four Vietnamese Infants (2020)
Preprint / Working Paper
Thanh, L. N., Trieu, T. T. H., Bui, H. T. .., Hoang, V. T., Nguyen, A. T. T., Trinh, N. T. H., Nguyen, K. T., & Hoang, D. M. Allogeneic Administration of Human Umbilical Cord-derived Mesenchymal Stem/Stromal Cells for Bronchopulmonary Dysplasia: Preliminary Outcomes in Four Vietnamese Infants

Background: Bronchopulmonary dysplasia (BPD) is a severe condition in premature infants that compromises lung function and necessitates oxygen support. Despite major improvements in perinatal care minimizing the devastating effects, BPD remains the m... Read More about Allogeneic Administration of Human Umbilical Cord-derived Mesenchymal Stem/Stromal Cells for Bronchopulmonary Dysplasia: Preliminary Outcomes in Four Vietnamese Infants.