Outputs (6)

Pentablock Thermoresponsive Hydrogels for Chemotherapeutic Delivery in a Pancreatic Cancer Model (2025)
Journal Article
Elsherbeny, A., Bayraltutan, H., Gumus, N., McCrorie, P., Garcia-Sampedro, A., Parmar, S., Ritchie, A., Meakin, M., Oz, U. C., Rahman, R., Ashworth, J. C., Grabowska, A. M., Moloney, C., & Alexander, C. (2025). Pentablock Thermoresponsive Hydrogels for Chemotherapeutic Delivery in a Pancreatic Cancer Model. Biomaterials Science, https://doi.org/10.1039/d4bm01629g

The design of biodegradable and thermoresponsive polymeric hydrogels with tuneable properties holds immense promise for localised and sustained drug delivery. In this study, we designed and synthesised a library of novel pentablock copolymers, incorp... Read More about Pentablock Thermoresponsive Hydrogels for Chemotherapeutic Delivery in a Pancreatic Cancer Model.

The role of mesenchymal cells in cholangiocarcinoma (2024)
Journal Article
Sueca-Comes, M., Rusu, E. C., Ashworth, J. C., Collier, P., Probert, C., Ritchie, A., Meakin, M., Mongan, N. P., Egbuniwe, I. U., Andersen, J. B., Bates, D. O., & Grabowska, A. M. (2024). The role of mesenchymal cells in cholangiocarcinoma. Disease Models and Mechanisms, 17(12), Article dmm050716. https://doi.org/10.1242/dmm.050716

The tumour microenvironment (TME) significantly influences tumour formation and progression through dynamic interactions. Cholangiocarcinoma (CCA), a highly desmoplastic tumour, lacks early diagnostic biomarkers and has limited effective treatments o... Read More about The role of mesenchymal cells in cholangiocarcinoma.

Modulation of the pre-metastatic bone niche: molecular changes mediated by bone-homing prostate cancer extracellular vesicles (2024)
Journal Article
Brown, T. J., Rutland, C. S., Rutland, C. S., Choi, K. K., Tse, F., Pfeffers, M. J., Peffers, M. J., Mongan, N. P., Arkill, K. P., Ritchie, A., Clarke, P. A., Ratan, H., Allegrucci, C., Grabowska, A. M., & James, V. (2024). Modulation of the pre-metastatic bone niche: molecular changes mediated by bone-homing prostate cancer extracellular vesicles. Frontiers in Cell and Developmental Biology, 12, Article 1354606. https://doi.org/10.3389/fcell.2024.1354606

Prostate cancer (PCa) is a leading male malignancy worldwide, often progressing to bone metastasis, with limited curative options. Extracellular vesicles (EVs) have emerged as key players in cancer communication and metastasis, promoting the formatio... Read More about Modulation of the pre-metastatic bone niche: molecular changes mediated by bone-homing prostate cancer extracellular vesicles.

Chain-extension in hyperbranched polymers alters tissue distribution and cytotoxicity profiles in orthotopic models of triple negative breast cancers (2023)
Journal Article
Moloney, C., Mehradnia, F., Cavanagh, R. J., Ibrahim, A., Pearce, A. K., Ritchie, A. A., Clarke, P., Rahman, R., Grabowska, A. M., & Alexander, C. (2023). Chain-extension in hyperbranched polymers alters tissue distribution and cytotoxicity profiles in orthotopic models of triple negative breast cancers. Biomaterials Science, 11, 6545-6560. https://doi.org/10.1039/d3bm00609c

The therapeutic efficacy of nanomedicines is highly dependent on their access to target sites in the body, and this in turn is markedly affected by their size, shape and transport properties in tissue. Although there have been many studies in this ar... Read More about Chain-extension in hyperbranched polymers alters tissue distribution and cytotoxicity profiles in orthotopic models of triple negative breast cancers.

Application of a 3D hydrogel-based model to replace use of animals for passaging patient-derived xenografts (2023)
Journal Article
Jones, S., Ashworth, J. C., Meakin, M., Collier, P., Probert, C., Ritchie, A. A., Merry, C. L. R., & Grabowska, A. M. (2023). Application of a 3D hydrogel-based model to replace use of animals for passaging patient-derived xenografts. In Vitro Models, 2(3-4), 99-111. https://doi.org/10.1007/s44164-023-00048-x

Purpose
This 3D in vitro cancer model for propagation of patient-derived cells, using a synthetic self-assembling peptide gel, allows the formation of a fully characterised, tailorable tumour microenvironment. Unlike many existing 3D cancer models,... Read More about Application of a 3D hydrogel-based model to replace use of animals for passaging patient-derived xenografts.

Clinically Translatable Transcrocetin Delivery Platform for Correction of Tumor Hypoxia and Enhancement of Radiation Therapy Effects (2023)
Journal Article
Diringer, M., Coliat, P., Mathieu, C., Laurent, N., Mura, C., Banerjee, M., Zhu, C., Grabowska, A., Ritchie, A., Clarke, P., Bernard, A., Vit, C., Burckel, H., Noel, G., Harvey, P., Pivot, X., & Detappe, A. (2023). Clinically Translatable Transcrocetin Delivery Platform for Correction of Tumor Hypoxia and Enhancement of Radiation Therapy Effects. Small, 19(12), Article 2205961. https://doi.org/10.1002/smll.202205961

Improving the tumor reoxygenation to sensitize the tumor to radiation therapy is a cornerstone in radiation oncology. Here, the pre‐clinical development of a clinically transferable liposomal formulation encapsulating trans sodium crocetinate (NP TSC... Read More about Clinically Translatable Transcrocetin Delivery Platform for Correction of Tumor Hypoxia and Enhancement of Radiation Therapy Effects.