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Outputs (18)

Fully angularly resolved 3D microrheology with optical tweezers (2024)
Journal Article
Matheson, A. B., Mendonca, T., Smith, M. G., Sutcliffe, B., Fernandez, A. J., Paterson, L., Dalgarno, P. A., Wright, A. J., & Tassieri, M. (2024). Fully angularly resolved 3D microrheology with optical tweezers. Rheologica Acta, 63(3), 205-217. https://doi.org/10.1007/s00397-024-01435-1

Microrheology with optical tweezers (MOT) is an all-optical technique that allows the user to investigate a materials’ viscoelastic properties at microscopic scales, and is particularly useful for those materials that feature complex microstructures,... Read More about Fully angularly resolved 3D microrheology with optical tweezers.

Effect of skin color on optical properties and the implications for medical optical technologies: a review (2024)
Journal Article
Setchfield, K., Gorman, A., Simpson, A. H. R. W., Somekh, M. G., & Wright, A. J. (2024). Effect of skin color on optical properties and the implications for medical optical technologies: a review. Journal of Biomedical Optics, 29(01), Article 010901. https://doi.org/10.1117/1.jbo.29.1.010901

Significance: Skin color affects light penetration leading to differences in its absorption and scattering properties. COVID-19 highlighted the importance of understanding of the interaction of light with different skin types, e.g., pulse oximetry (P... Read More about Effect of skin color on optical properties and the implications for medical optical technologies: a review.

Relevance and utility of the in-vivo and ex-vivo optical properties of the skin reported in the literature: a review [Invited] (2023)
Journal Article
Setchfield, K., Gorman, A., Simpson, A. H. R. W., Somekh, M. G., & Wright, A. J. (2023). Relevance and utility of the in-vivo and ex-vivo optical properties of the skin reported in the literature: a review [Invited]. Biomedical Optics Express, 14(7), 3555-3583. https://doi.org/10.1364/boe.493588

Imaging non-invasively into the human body is currently limited by cost (MRI and CT scan), image resolution (ultrasound), exposure to ionising radiation (CT scan and X-ray), and the requirement for exogenous contrast agents (CT scan and PET scan). Op... Read More about Relevance and utility of the in-vivo and ex-vivo optical properties of the skin reported in the literature: a review [Invited].

Living cells as a biological analog of optical tweezers – a non-invasive microrheology approach (2023)
Journal Article
Hardiman, W., Clark, M., Friel, C., Huett, A., Pérez-Cota, F., Setchfield, K., Wright, A. J., & Tassieri, M. (2023). Living cells as a biological analog of optical tweezers – a non-invasive microrheology approach. Acta Biomaterialia, 166, 317-325. https://doi.org/10.1016/j.actbio.2023.04.039

Microrheology, the study of fluids on micron length-scales, promises to reveal insights into cellular biology, including mechanical biomarkers of disease and the interplay between biomechanics and cellular function. Here a minimally-invasive passive... Read More about Living cells as a biological analog of optical tweezers – a non-invasive microrheology approach.

OptoRheo: Simultaneous in situ micro-mechanical sensing and imaging of live 3D biological systems (2023)
Journal Article
Mendonca, T., Lis-Slimak, K., Matheson, A. B., Smith, M. G., Anane-Adjei, A. B., Ashworth, J. C., Cavanagh, R., Paterson, L., Dalgarno, P. A., Alexander, C., Tassieri, M., Merry, C. L. R., & Wright, A. J. (2023). OptoRheo: Simultaneous in situ micro-mechanical sensing and imaging of live 3D biological systems. Communications Biology, 6, Article 463. https://doi.org/10.1038/s42003-023-04780-8

Biomechanical cues from the extracellular matrix (ECM) are essential for directing many cellular processes, from normal development and repair, to disease progression. To better understand cell-matrix interactions, we have developed a new instrument... Read More about OptoRheo: Simultaneous in situ micro-mechanical sensing and imaging of live 3D biological systems.

Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML (2023)
Journal Article
James, J. R., Curd, J., Ashworth, J. C., Abuhantash, M., Grundy, M., Seedhouse, C. H., Arkill, K. P., Wright, A. J., Merry, C. L. R., & Thompson, A. (2023). Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML. International Journal of Molecular Sciences, 24(4), Article 4235. https://doi.org/10.3390/ijms24044235

In vivo models of acute myeloid leukemia (AML) are low throughput, and standard liquid culture models fail to recapitulate the mechanical and biochemical properties of the extracellular matrix-rich protective bone marrow niche that contributes to dru... Read More about Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML.

OptoRheo: Simultaneous in situ micro-mechanical sensing and 3D imaging of live cell cultures (2023)
Preprint / Working Paper
Mendonca, T., Lis-Slimak, K., Matheson, A. B., Smith, M. G., Anane-Adjei, A. B., Cavanagh, R., Paterson, L., Dalgarno, P. A., Alexander, C., Tassieri, M., Merry, C. L. R., & Wright, A. J. OptoRheo: Simultaneous in situ micro-mechanical sensing and 3D imaging of live cell cultures

Biomechanical cues from the extracellular matrix (ECM) are essential for directing many cellular processes, from normal development and repair, to disease progression. To better understand cell-matrix interactions, we have developed a new instrument... Read More about OptoRheo: Simultaneous in situ micro-mechanical sensing and 3D imaging of live cell cultures.

C-terminal citrullinated peptide alters antigen-specific APC:T cell interactions leading to breach of immune tolerance (2023)
Journal Article
Malcolm, J., Nyirenda, M. H., Brown, J. L., Adrados-Planell, A., Campbell, L., Butcher, J. P., Glass, D. G., Piela, K., Goodyear, C. S., Wright, A. J., McInnes, I. B., Millington, O. R., & Culshaw, S. (2023). C-terminal citrullinated peptide alters antigen-specific APC:T cell interactions leading to breach of immune tolerance. Journal of Autoimmunity, 135, Article 102994. https://doi.org/10.1016/j.jaut.2023.102994

In rheumatoid arthritis, the emergence of anti-citrullinated autoimmunity is associated with HLA-antigen-T cell receptor complexes. The precise mechanisms underpinning this breach of tolerance are not well understood. Porphyromonas gingivalis express... Read More about C-terminal citrullinated peptide alters antigen-specific APC:T cell interactions leading to breach of immune tolerance.

Non-iterative aberration retrieval based on the spot shape around focus (2022)
Journal Article
Smid, P., See, C. W., Somekh, M. G., & Wright, A. J. (2022). Non-iterative aberration retrieval based on the spot shape around focus. Optics and Lasers in Engineering, 157, Article 107108. https://doi.org/10.1016/j.optlaseng.2022.107108

A non-iterative, robust, aberration retrieval method to determine primary aberrations by utilizing the intensity distribution at and around focus is presented. The primary Zernike aberrations (coma, spherical aberration and astigmatism) are retrieved... Read More about Non-iterative aberration retrieval based on the spot shape around focus.