Outputs (2)

The Leydig cell biomarker INSL3 as a predictor of age-related morbidity: Findings from the EMAS cohort (2022)
Journal Article
Ivell, R., Heng, K., Severn, K., Antonio, L., Bartfai, G., Casanueva, F. F., Huhtaniemi, I. T., Giwercman, A., Maggi, M., O’Connor, D. B., O’Neill, T. W., Punab, M., Rastrelli, G., Slowikowska-Hilczer, J., Tournoy, J., Vanderschueren, D., Wu, F. C. W., & Anand-Ivell, R. (2022). The Leydig cell biomarker INSL3 as a predictor of age-related morbidity: Findings from the EMAS cohort. Frontiers in Endocrinology, 13, Article 1016107. https://doi.org/10.3389/fendo.2022.1016107

Background: Insulin-like peptide 3 (INSL3) is a constitutive hormone secreted in men by the mature Leydig cells of the testes. It is an accurate biomarker for Leydig cell functional capacity, reflecting their total cell number and differentiation sta... Read More about The Leydig cell biomarker INSL3 as a predictor of age-related morbidity: Findings from the EMAS cohort.

Association of age, hormonal, and lifestyle factors with the Leydig cell biomarker INSL3 in aging men from the European Male Aging Study cohort (2022)
Journal Article
Anand-Ivell, R., Heng, K., Severn, K., Antonio, L., Bartfai, G., Casanueva, F. F., Huhtaniemi, I. T., Giwercman, A., Maggi, M., O'Neill, T. W., Punab, M., Rastrelli, G., Slowikowska‐Hilczer, J., Tournoy, J., Vanderschueren, D., Wu, F. C., & Ivell, R. (2022). Association of age, hormonal, and lifestyle factors with the Leydig cell biomarker INSL3 in aging men from the European Male Aging Study cohort. Andrology, 10(7), 1328-1338. https://doi.org/10.1111/andr.13220

Background: Aging in men is accompanied by a broad range of symptoms, including sexual dysfunction, cognitive and musculoskeletal decline, obesity, type 2 diabetes, cardiovascular disease and hypertension, organ degeneration/failure, and increasing n... Read More about Association of age, hormonal, and lifestyle factors with the Leydig cell biomarker INSL3 in aging men from the European Male Aging Study cohort.