Skip to main content

Research Repository

Advanced Search

Outputs (1727)

A range of voltage-clamp protocol designs for rapid capture of hERG kinetics (2024)
Preprint / Working Paper
Lei, C. L., Whittaker, D. G., Windley, M. J., Perry, M. D., Hill, A. P., & Mirams, G. R. A range of voltage-clamp protocol designs for rapid capture of hERG kinetics

We provide details of a series of short voltage-clamp protocols designed for gathering a large amount of information on hERG (Kv11.1) ion channel gating. The protocols have a limited number of steps and consist only of steps and ramps, making them ea... Read More about A range of voltage-clamp protocol designs for rapid capture of hERG kinetics.

Geometry of Spin(10) symmetry breaking (2024)
Journal Article
Krasnov, K. (2024). Geometry of Spin(10) symmetry breaking. Journal of Mathematical Physics, 65(8), Article 082302. https://doi.org/10.1063/5.0210073

We provide a new characterisation of the Standard Model gauge group GSM as a subgroup of Spin(10). The new description of GSM relies on the geometry of pure spinors. We show that GSM ⊂ Spin(10) is the group that stabilises a pure spinor Ψ1 and projec... Read More about Geometry of Spin(10) symmetry breaking.

Investigative power of Genomic Informational Field Theory (GIFT) relative to GWAS for genotype-phenotype mapping (2024)
Preprint / Working Paper
Kyratzi, P., Matika, O., Brassington, A. H., Connie, C. E., Xu, J., Barrett, D. A., Emes, R. D., Archibald, A. L., Paldi, A., Sinclair, K. D., Wattis, J., & Rauch, C. Investigative power of Genomic Informational Field Theory (GIFT) relative to GWAS for genotype-phenotype mapping

Identifying associations between phenotype and genotype is the fundamental basis of genetic analyses. Inspired by frequentist probability and the work of R.A. Fisher, genome-wide association studies (GWAS) extract information using averages and varia... Read More about Investigative power of Genomic Informational Field Theory (GIFT) relative to GWAS for genotype-phenotype mapping.

The Conversationality Index: A quantitative assessment of conversation in social media interactions (2024)
Journal Article
Cotgrove, L., Thul, R., & Conklin, K. (in press). The Conversationality Index: A quantitative assessment of conversation in social media interactions. Internet Pragmatics,

There has been an explosion in social media use, with Statista estimating that worldwide, Facebook has over 3 billion regular active users, YouTube 2.5 billion, and Instagram and WhatsApp 2 billion. While social media allows one to connect and intera... Read More about The Conversationality Index: A quantitative assessment of conversation in social media interactions.

Deep NURBS—admissible physics-informed neural networks (2024)
Journal Article
Saidaoui, H., Espath, L., & Tempone, R. (2024). Deep NURBS—admissible physics-informed neural networks. Engineering with Computers, https://doi.org/10.1007/s00366-024-02040-9

In this study, we propose a new numerical scheme for physics-informed neural networks (PINNs) that enables precise and inexpensive solutions for partial differential equations (PDEs) in case of arbitrary geometries while strongly enforcing Dirichlet... Read More about Deep NURBS—admissible physics-informed neural networks.

Nonassociative cyclic algebras and the semiassociative Brauer monoid (2024)
Journal Article
Pumplün, S. (2024). Nonassociative cyclic algebras and the semiassociative Brauer monoid. Rendiconti del Circolo Matematico di Palermo, https://doi.org/10.1007/s12215-024-01105-4

We look at classes of semiassociative algebras, with an emphasis on those that canonically generalize associative (generalized) cyclic algebras, and at their behaviour in the semiassociative Brauer monoid defined by Blachar, Haile, Matzri, Rein, an... Read More about Nonassociative cyclic algebras and the semiassociative Brauer monoid.

How to correctly fit an SIR model to data from an SEIR model? (2024)
Journal Article
KhudaBukhsh, W. R., & Rempała, G. A. (2024). How to correctly fit an SIR model to data from an SEIR model?. Mathematical Biosciences, 375, Article 109265. https://doi.org/10.1016/j.mbs.2024.109265

In epidemiology, realistic disease dynamics often require Susceptible-Exposed-Infected-Recovered (SEIR)-like models because they account for incubation periods before individuals become infectious. However, for the sake of analytica... Read More about How to correctly fit an SIR model to data from an SEIR model?.

Lubrication flow in grinding (2024)
Journal Article
Crowson, Z., Billingham, J., & Houston, P. (2024). Lubrication flow in grinding. Journal of Engineering Mathematics, 147(1), Article 12. https://doi.org/10.1007/s10665-024-10383-x

In the machining process known as grinding, fluid is applied to regulate the temperature of the workpiece and reduce the risk of expensive thermal damage. The factors that influence the transport of this grinding fluid are not well understood; howeve... Read More about Lubrication flow in grinding.

Resolving artefacts in voltage-clamp experiments with computational modelling: an application to fast sodium current recordings (2024)
Preprint / Working Paper
Lei, C. L., Clark, A. P., Clerx, M., Wei, S., Bloothooft, M., de Boer, T. P., Christini, D. J., Krogh-Madsen, T., & Mirams, G. R. Resolving artefacts in voltage-clamp experiments with computational modelling: an application to fast sodium current recordings

Cellular electrophysiology is the foundation of many fields, from basic science in neurology, cardiology, oncology to safety critical applications for drug safety testing, clinical phenotyping, etc. Patch-clamp voltage clamp is the gold standard tech... Read More about Resolving artefacts in voltage-clamp experiments with computational modelling: an application to fast sodium current recordings.