Structure activity relationships of αv integrin antagonists for pulmonary fibrosis by variation in aryl substituents
(2014)
Journal Article
Adams, J., Anderson, E. C., Blackham, E. E., Chiu, Y. W. R., Clarke, T., Eccles, N., Gill, L. A., Haye, J. J., Haywood, H. T., Hoenig, C. R., Russell, H. L., Smedley, C., Tipping, W. J., Tongue, T., Wood, C. C., Yeung, J., Rowedder, J. E., Fray, M. J., Mcinally, T., & Macdonald, S. J. (2014). Structure activity relationships of αv integrin antagonists for pulmonary fibrosis by variation in aryl substituents. ACS Medicinal Chemistry Letters, 5(11), https://doi.org/10.1021/ml5002079
Antagonism of alphav beta6 is emerging as a potential treatment of idiopathic pulmonary fibrosis based on strong target validation. Starting from an alphav beta3 antagonist lead and through simple variation in the nature and position of aryl substit... Read More about Structure activity relationships of αv integrin antagonists for pulmonary fibrosis by variation in aryl substituents.