A glycopeptide dendrimer inhibitor of the galactose specific lectin LecA & of Pseudomonas aeruginosa biofilms
(2011)
Journal Article
Kadam, R. U., Bergmann, M., Hurley, M., Garg, D., Cacciarini, M., Swiderska, M. A., Nativi, C., Sattler, M., Smyth, A. R., Williams, P., Cámara, M., Stocker, A., Darbre, T., & Reymond, J.-L. (2011). A glycopeptide dendrimer inhibitor of the galactose specific lectin LecA & of Pseudomonas aeruginosa biofilms. Angewandte Chemie International Edition, 50(45), https://doi.org/10.1002/anie.201104342
Biofilm inhibition is achieved with a phenylgalactosyl peptide dendrimer (see picture) that binds to the galactose-specific lectin LecA of P. aeruginosa. The multivalency of the ligands is critical for biofilm inhibition, although the nature of the l... Read More about A glycopeptide dendrimer inhibitor of the galactose specific lectin LecA & of Pseudomonas aeruginosa biofilms.