Outputs (137)

A paper-based in vitro model for on-chip investigation of the human respiratory system (2016)
Journal Article
Rahimi, R., Htwe, S. S., Ochoa, M., Donaldson, A., Zieger, M., Sood, R., …Ziaie, B. (in press). A paper-based in vitro model for on-chip investigation of the human respiratory system. Lab on a Chip, 16(22), https://doi.org/10.1039/C6LC00866F

Culturing cells at the air–liquid interface (ALI) is essential for creating functional in vitro models of lung tissues. We present the use of direct-patterned laser-treated hydrophobic paper as an effective semi-permeable membrane, ideal for ALI cell... Read More about A paper-based in vitro model for on-chip investigation of the human respiratory system.

Effective antigen presentation to helper T cells by human eosinophils (2016)
Journal Article
Farhan, R. K., Vickers, M. A., Ghaemmaghami, A. M., Hall, A. M., Barker, R. N., & Walsh, G. M. (in press). Effective antigen presentation to helper T cells by human eosinophils. Immunology, https://doi.org/10.1111/imm.12658

Although eosinophils are inflammatory cells, there is increasing attention on their immunomodulatory roles. For example, murine eosinophils can present antigen to CD4+ T helper (Th) cells, but it remains unclear whether human eosinophils also have th... Read More about Effective antigen presentation to helper T cells by human eosinophils.

A novel ketone diet enhances physical and cognitive performance (2016)
Journal Article
Murray, A. J., Knight, N. S., Cole, M. A., Cochlin, L. E., Carter, E., Tchabanenko, K., …Clarke, K. (2016). A novel ketone diet enhances physical and cognitive performance. FASEB Journal, 30(12), 4021-4032. https://doi.org/10.1096/fj.201600773R

Ketone bodies are the most energy efficient fuel, yielding more ATP per mole of substrate than pyruvate and increasing the free energy released from ATP hydrolysis. Elevation of circulating ketones via high-fat, low-carbohydrate diets has been used f... Read More about A novel ketone diet enhances physical and cognitive performance.

Assessment of a rapid liquid-based cytology method for measuring sputum cell counts (2016)
Journal Article
Martin, M., Lee, H., Meakin, G., Green, A., Simms, R., Reynolds, C., …Harrison, T. W. (in press). Assessment of a rapid liquid-based cytology method for measuring sputum cell counts. Thorax, https://doi.org/10.1136/thoraxjnl-2016-208817

Differential sputum cell counting is not widely available despite proven clinical utility in the management of asthma. We compared eosinophil counts obtained using liquid-based cytology (LBC), a routine histopathological processing method, and the cu... Read More about Assessment of a rapid liquid-based cytology method for measuring sputum cell counts.

In vitro models of medulloblastoma: choosing the right tool for the job (2016)
Journal Article
Ivanov, D. P., Coyle, B., Walker, D. A., & Grabowska, A. M. (2016). In vitro models of medulloblastoma: choosing the right tool for the job. Journal of Biotechnology, 236, 10-25. https://doi.org/10.1016/j.jbiotec.2016.07.028

The recently-defined four molecular subgroups of medulloblastoma have required updating of our understanding of in vitro models to include molecular classification and risk stratification features from clinical practice. This review seeks to build a... Read More about In vitro models of medulloblastoma: choosing the right tool for the job.

A qualitative study of professional and carer perceptions of the threats to safe hospital discharge for stroke and hip fracture patients in the English National Health Service (2016)
Journal Article
Waring, J., Bishop, S., & Marshall, F. (in press). A qualitative study of professional and carer perceptions of the threats to safe hospital discharge for stroke and hip fracture patients in the English National Health Service. BMC Health Services Research, 16, https://doi.org/10.1186/s12913-016-1568-2

Background: Hospital discharge is a vulnerable transitional stage in patient care. This qualitative study investigated the views of healthcare professionals and patients about the threats to safe hospital discharge with aim of identifying contributor... Read More about A qualitative study of professional and carer perceptions of the threats to safe hospital discharge for stroke and hip fracture patients in the English National Health Service.

Individual placement and support (IPS) for patients with offending histories: the IPSOH feasibility cluster randomised trial protocol (2016)
Journal Article
Khalifa, N., Talbot, E., Schneider, J. M., Walker, D., Bates, P., Bird, Y., …Völlm, B. (2016). Individual placement and support (IPS) for patients with offending histories: the IPSOH feasibility cluster randomised trial protocol. BMJ Open, 6(7), Article e012710. https://doi.org/10.1136/bmjopen-2016-012710

Introduction: People with involvement in forensic psychiatric services face many obstacles to employment, arising from their offending, as well as their mental health problems. This study aims to assess the feasibility of conducting a randomised cont... Read More about Individual placement and support (IPS) for patients with offending histories: the IPSOH feasibility cluster randomised trial protocol.

Application of novel analytical ultracentrifuge analysis to solutions of fungal mannans (2016)
Journal Article
Gillis, R. B., Adams, G. G., Besong, D. T., Machová, E., Ebringerová, A., Rowe, A. J., …Patel, T. R. (2017). Application of novel analytical ultracentrifuge analysis to solutions of fungal mannans. European Biophysics Journal, 46(3), 235-245. https://doi.org/10.1007/s00249-016-1159-5

Polysaccharides, the most abundant biopolymers, are required for a host of activities in lower organisms, animals, and plants. Their solution characterization is challenging due to their complex shape, heterogeneity, and size. Here, recently develope... Read More about Application of novel analytical ultracentrifuge analysis to solutions of fungal mannans.

Drug-like antagonists of P2Y receptors — from lead identification to drug development (2016)
Journal Article
Conroy, S., Kindon, N., Kellam, B., & Stocks, M. (in press). Drug-like antagonists of P2Y receptors — from lead identification to drug development. Journal of Medicinal Chemistry, https://doi.org/10.1021/acs.jmedchem.5b01972

P2Y receptors are expressed in virtually all cells and tissue types and mediate an astonishing array of biological functions, including platelet aggregation, smooth muscle cell proliferation, and immune regulation. The P2Y receptors belong to the G p... Read More about Drug-like antagonists of P2Y receptors — from lead identification to drug development.

Outcomes after successful direct-acting antiviral therapy for patients with chronic hepatitis C and decompensated cirrhosis (2016)
Journal Article
Cheung, M. C., Walker, A. J., Hudson, B. E., Verma, S., McLauchlan, J., Mutimer, D. J., …Irving, W. L. (2016). Outcomes after successful direct-acting antiviral therapy for patients with chronic hepatitis C and decompensated cirrhosis. Journal of Hepatology, 65(4), 741-747. https://doi.org/10.1016/j.jhep.2016.06.019

Direct-acting antivirals have become widely used for patients with chronic hepatitis C virus infection with decompensated cirrhosis. Virological responses are excellent and early improvements in liver function, at least in a proportion of patients, h... Read More about Outcomes after successful direct-acting antiviral therapy for patients with chronic hepatitis C and decompensated cirrhosis.