Outputs (33)

Smoking, nicotine and pregnancy 2 (SNAP2) trial: protocol for a randomised controlled trial of an intervention to improve adherence to nicotine replacement therapy during pregnancy (2024)
Journal Article
Clark, M. M., Cooper, S., Naughton, F., Ussher, M., Emery, J., McDaid, L., Thomson, R., Phillips, L., Bauld, L., Aveyard, P., Torgerson, D., Berlin, I., Lewis, S., Parrott, S., Hewitt, C., Welch, C., Parkinson, G., Dickinson, A., Sutton, S., Brimicombe, J., …Coleman, T. (2024). Smoking, nicotine and pregnancy 2 (SNAP2) trial: protocol for a randomised controlled trial of an intervention to improve adherence to nicotine replacement therapy during pregnancy. BMJ Open, 14(5), Article e087175. https://doi.org/10.1136/bmjopen-2024-087175

IntroductionSmoking during pregnancy is harmful to unborn babies, infants and women. Nicotine replacement therapy (NRT) is offered as the usual stop-smoking support in the UK. However, this is often used in insufficient doses, intermittently or for t... Read More about Smoking, nicotine and pregnancy 2 (SNAP2) trial: protocol for a randomised controlled trial of an intervention to improve adherence to nicotine replacement therapy during pregnancy.

A multifaceted and standardized approach is needed to improve acne severity assessment in clinical practice: an online survey of UK health professionals (2024)
Journal Article
Masterson, N., Burden-Teh, E., Healy, E., Hepburn, T., Layfield, C., Layton, A., Leighton, P., Leng, S., Mitchell, E., Northover, G., Penzer-Hick, R., Price, W., Radley, K., Ramesh, G., Ravenscroft, J. C., Sach, T., Sadiq, S., Santer, M., Thomas, K. S., Thompson, A., …the Acne-ID Trial Development Team. (2025). A multifaceted and standardized approach is needed to improve acne severity assessment in clinical practice: an online survey of UK health professionals. Clinical and Experimental Dermatology, 50(1), 158-160. https://doi.org/10.1093/ced/llae180

Long acting progestogens versus combined oral contraceptive pill for preventing recurrence of endometriosis related pain: the PRE-EMPT pragmatic, parallel group, open label, randomised controlled trial (2024)
Journal Article
Cooper, K. G., Bhattacharya, S., Daniels, J. P., Horne, A. W., Clark, T. J., Saridogan, E., Cheed, V., Pirie, D., Melyda, M., Monahan, M., Roberts, T. E., Cox, E., Stubbs, C., Middleton, L. J., & on behalf of the PRE-EMPT Collaborative Group. (in press). Long acting progestogens versus combined oral contraceptive pill for preventing recurrence of endometriosis related pain: the PRE-EMPT pragmatic, parallel group, open label, randomised controlled trial. BMJ, 385, e079006. https://doi.org/10.1136/bmj-2023-079006

Objectives: To evaluate the clinical effectiveness of long acting progestogens compared with the combined oral contraceptive pill in preventing recurrence of endometriosis related pain. Design: The PRE-EMPT (preventing recurrence of endometriosis) pr... Read More about Long acting progestogens versus combined oral contraceptive pill for preventing recurrence of endometriosis related pain: the PRE-EMPT pragmatic, parallel group, open label, randomised controlled trial.

A mixed-methods study to investigate feasibility and acceptability of an early warning score for preterm infants in neonatal units in Kenya: results of the NEWS-K study (2024)
Journal Article
Mitchell, E. J., Aluvaala, J., Bradshaw, L., Daniels, J. P., Emadau, C., Muthumbi, B., Nabwera, H., Ojee, E., Opira, J., Pallotti, P., Qureshi, Z., Sigei, M., Su, Y., Swinden, R., Were, F., & Ojha, S. (2024). A mixed-methods study to investigate feasibility and acceptability of an early warning score for preterm infants in neonatal units in Kenya: results of the NEWS-K study. BMC Pediatrics, 24, Article 326. https://doi.org/10.1186/s12887-024-04778-z

Preterm birth (< 37 weeks gestation) complications are the leading cause of neonatal mortality. Early-warning scores (EWS) are charts where vital signs (e.g., temperature, heart rate, respiratory rate) are recorded, triggering action. To evaluate whe... Read More about A mixed-methods study to investigate feasibility and acceptability of an early warning score for preterm infants in neonatal units in Kenya: results of the NEWS-K study.

Metformin for endometrial hyperplasia (2024)
Journal Article
Shiwani, H., Clement, N. S., Daniels, J. P., & Atiomo, W. (2024). Metformin for endometrial hyperplasia. Cochrane Database of Systematic Reviews, 2024(5), Article CD012214. https://doi.org/10.1002/14651858.cd012214.pub3

Background
Endometrial cancer is one of the most common gynaecological cancers in the world. Rates of endometrial cancer are rising, in part because of rising obesity rates. Endometrial hyperplasia is a precancerous condition in women that can lead... Read More about Metformin for endometrial hyperplasia.

Current usage of explainer animations in trials: a survey of the UKCRC registered clinical trial units in the UK (2024)
Journal Article
Barber, V. S., Calvert, C., Appelbe, D., Sprange, K., Nollett, C., Tanner, S., & Richards, D. B. (2024). Current usage of explainer animations in trials: a survey of the UKCRC registered clinical trial units in the UK. Trials, 25, Article 224. https://doi.org/10.1186/s13063-024-08060-6

Background
Explainer animations are a means to communicate aspects of clinical trials to participants in a more engaging and accessible way. Delivered well these have the potential to enhance recruitment and retention. The range of media technology... Read More about Current usage of explainer animations in trials: a survey of the UKCRC registered clinical trial units in the UK.

Precision computerised cognitive behavioural therapy (cCBT) for adolescents with depression: a pilot and feasibility randomised controlled trial protocol for SPARX-UK (2024)
Journal Article
Khan, K., Hall, C. L., Babbage, C., Dodzo, S., Greenhalgh, C., Lucassen, M., Merry, S., Sayal, K., Sprange, K., Stasiak, K., Tench, C. R., Townsend, E., Stallard, P., & Hollis, C. (2024). Precision computerised cognitive behavioural therapy (cCBT) for adolescents with depression: a pilot and feasibility randomised controlled trial protocol for SPARX-UK. Pilot and Feasibility Studies, 10(1), Article 53. https://doi.org/10.1186/s40814-024-01475-7

Background : A serious game called SPARX (Smart, Positive, Active, Realistic, X-factor thoughts), originally developed in New Zealand and incorporating cognitive behavioural therapy (CBT) principles, has been shown to help reduce symptoms of depressi... Read More about Precision computerised cognitive behavioural therapy (cCBT) for adolescents with depression: a pilot and feasibility randomised controlled trial protocol for SPARX-UK.

Recording harms in randomised controlled trials of behaviour change interventions: a qualitative study of UK clinical trials units and NIHR trial investigators (2024)
Journal Article
Papaioannou, D., Sprange, K., Hamer-Kiwacz, S., Mooney, C., Moody, G., & Cooper, C. (2024). Recording harms in randomised controlled trials of behaviour change interventions: a qualitative study of UK clinical trials units and NIHR trial investigators. Trials, 25(1), Article 163. https://doi.org/10.1186/s13063-024-07978-1

Background: Harms, also known as adverse events (AEs), are recorded and monitored in randomised controlled trials (RCTs) to ensure participants’ safety. Harms are recorded poorly or inconsistently in RCTs of Behaviour Change Interventions (BCI); howe... Read More about Recording harms in randomised controlled trials of behaviour change interventions: a qualitative study of UK clinical trials units and NIHR trial investigators.

Recording harms in randomized controlled trials of behavior change interventions: a scoping review and map of the evidence (2024)
Journal Article
Papaioannou, D., Hamer-Kiwacz, S., Mooney, C., Cooper, C., O'Cathain, A., Sprange, K., & Moody, G. (2024). Recording harms in randomized controlled trials of behavior change interventions: a scoping review and map of the evidence. Journal of Clinical Epidemiology, 169, Article 111275. https://doi.org/10.1016/j.jclinepi.2024.111275

Objectives: Randomized controlled trials evaluate diverse interventions. This can include medical interventions such as drugs or surgical procedures, or behavior change interventions (BCIs) that aim to change a habit, belief, or attitude to improve h... Read More about Recording harms in randomized controlled trials of behavior change interventions: a scoping review and map of the evidence.

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial (2024)
Journal Article
RECOVERY Collaborative Group, Sandercock, P., Darbyshire, J., DeMets, D., Fowler, R., Lalloo, D., Munavvar, M., Warris, A., Wittes, J., Cradduck-Bamford, A., Barton, J., Basoglu, A., Brown, R., Brudlo, W., Denis, E., Fletcher, L., Howard, S., Taylor, K., Cui, G., Goodenough, B., …Local Clinical Centre staff (for the RECOVERY Collaborative Group). (in press). Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Nature Communications, 15, Article 924. https://doi.org/10.1038/s41467-023-43644-x

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOV... Read More about Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.