Outputs (34)

Pan-colonic pressurizations associated with relaxation of the anal sphincter in health and disease: a new colonic motor pattern identified using high-resolution manometry (2016)
Journal Article
Corsetti, M., Pagliaro, G., Demedts, I., Deloose, E., Gevers, A., Scheerens, C., Rommel, N., & Tack, J. (2017). Pan-colonic pressurizations associated with relaxation of the anal sphincter in health and disease: a new colonic motor pattern identified using high-resolution manometry. American Journal of Gastroenterology, 112(3), https://doi.org/10.1038/ajg.2016.341

Background: Only few studies have applied high-resolution manometry (HRM) to the study of colonic motility in adults and none of them have concurrently evaluated colonic and anal motor activity. Aims: To evaluate colonic and anal motor activity by me... Read More about Pan-colonic pressurizations associated with relaxation of the anal sphincter in health and disease: a new colonic motor pattern identified using high-resolution manometry.

Effect of Helicobacter pylori infection on growth trajectories in young Ethiopian children: a longitudinal study (2016)
Journal Article
Taye, B., Enquselassie, F., Tsegaye, A., Amberbir, A., Medhin, G., Fogarty, A., Robinson, K., & Davey, G. (2016). Effect of Helicobacter pylori infection on growth trajectories in young Ethiopian children: a longitudinal study. International Journal of Infectious Diseases, 50, 57-66. https://doi.org/10.1016/j.ijid.2016.08.005

Background
Helicobacter pylori infection has been associated with early childhood growth impairment in high- and middle-income countries; however, few studies have examined this relationship within low-income countries or have used a longitudinal de... Read More about Effect of Helicobacter pylori infection on growth trajectories in young Ethiopian children: a longitudinal study.

A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis (2016)
Journal Article
Rivas, M. A., Graham, D., Sulem, P., Stevens, C., Nicole Desch, A., Goyette, P., Gudbjartsson, D., Jonsdottir, I., Thorsteinsdottir, U., Degenhardt, F., Mucha, S., Kurki, M. I., Li, D., D’Amato, M., Annese, V., Vermeire, S., Weersma, R. K., Halfvarson, J., Paavola-Sakki, P., Lappalainen, M., …Hawkey, C. (2016). A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis. Nature Communications, 7, 1-8. https://doi.org/10.1038/ncomms12342

Protein-truncating variants protective against human disease provide in vivo validation of therapeutic targets. Here we used targeted sequencing to conduct a search for protein-truncating variants conferring protection against inflammatory bowel dise... Read More about A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.

A genetic assay for gene essentiality in Clostridium (2016)
Journal Article
Walker, D. J., Heap, J. T., Winzer, K., & Minton, N. P. (2016). A genetic assay for gene essentiality in Clostridium. Anaerobe, 42, 40-43. https://doi.org/10.1016/j.anaerobe.2016.07.007

Essential genes of pathogens are potential therapeutic targets, but are difficult to verify. Here, gene essentiality was determined by targeted knockout following engineered gene duplication. Null mutants of candidate essential genes of Clostridium d... Read More about A genetic assay for gene essentiality in Clostridium.

Major abdominal surgery in Jehovah’s Witnesses (2016)
Journal Article
Rollins, K. E., Contractor, U., Inumerable, R., & Lobo, D. N. (2016). Major abdominal surgery in Jehovah’s Witnesses. Annals of The Royal College of Surgeons of England, 98(8), https://doi.org/10.1308/rcsann.2016.0210

Introduction

Patients who are Jehovah’s Witnesses pose difficult ethical and moral dilemmas for surgeons because of their refusal to receive blood and blood products. This article outlines the personal experiences of six Jehovah’s Witnesses who un... Read More about Major abdominal surgery in Jehovah’s Witnesses.

Biomarkers of liver fibrosis (2016)
Journal Article
Morling, J. R., & Guha, I. N. (in press). Biomarkers of liver fibrosis. Clinical Liver Disease, 7(6), https://doi.org/10.1002/cld.555

Currently the only accepted method (gold standard) for the diagnosis of the fibrotic stages of chronic liver disease (CLD) is liver biopsy, to allow histological assessment. Liver biopsy is an invasive investigation associated with a range adverse ev... Read More about Biomarkers of liver fibrosis.

Ustekinumab: a novel therapeutic option in Crohn's disease (2016)
Journal Article
E. G., S., S., S., S., G., & G. W., M. (2016). Ustekinumab: a novel therapeutic option in Crohn's disease. Expert Opinion on Biological Therapy, 16(8), 1065-1074. https://doi.org/10.1080/14712598.2016.1205582

A roadmap for gene system development in Clostridium (2016)
Journal Article
Minton, N. P., Ehsaan, M., Humphreys, C. M., Little, G. T., Baker, J., Henstra, A. M., Liew, F., Kelly, M., Sheng, L., Schwarz, K., & Zhang, Y. (2016). A roadmap for gene system development in Clostridium. Anaerobe, 41, 104-112. https://doi.org/10.1016/j.anaerobe.2016.05.011

Clostridium species are both heroes and villains. Some cause serious human and animal diseases, those present in the microbiota contribute to health and wellbeing, while others represent useful industrial chassis for the production of chemicals and f... Read More about A roadmap for gene system development in Clostridium.

Contemporary review of risk-stratified management in acute uncomplicated and complicated diverticulitis (2016)
Journal Article
Boermeester, M. A., Humes, D., Velmahos, G. C., & Søreide, K. (in press). Contemporary review of risk-stratified management in acute uncomplicated and complicated diverticulitis. World Journal of Surgery, 40(10), https://doi.org/10.1007/s00268-016-3560-8

BACKGROUND: Acute colonic diverticulitis is a common clinical condition. Severity of the disease is based on clinical, laboratory, and radiological investigations and dictates the need for medical or surgical intervention. Recent clinical trials have... Read More about Contemporary review of risk-stratified management in acute uncomplicated and complicated diverticulitis.

Helicobacter pylori vacA transcription is genetically-determined and stratifies the level of human gastric inflammation and atrophy (2016)
Journal Article
Sinnett, C. G., Letley, D. P., Narayana, G. L., Patel, S. R., Hussein, N. R., Zaitoun, A. M., Robinson, K., & Atherton, J. C. (2016). Helicobacter pylori vacA transcription is genetically-determined and stratifies the level of human gastric inflammation and atrophy. Journal of Clinical Pathology, 69(11), 968-973. https://doi.org/10.1136/jclinpath-2016-203641

Aims Helicobacter pylori infection is the major cause of peptic ulceration and gastric cancer, and an important virulence determinant is its vacuolating cytotoxin, vacA. Previously, we have described allelic variation in vacA which determines toxin a... Read More about Helicobacter pylori vacA transcription is genetically-determined and stratifies the level of human gastric inflammation and atrophy.