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Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in bile acid-farnesoid X receptor-fibroblast growth factor pathway (2018)
Journal Article
Monaghan, T. M., Mullish, B. H., Patterson, J., Wong, G. K., Marchesi, J. R., Xu, H., Tahseen, J., & Kao, D. (2018). Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in bile acid-farnesoid X receptor-fibroblast growth factor pathway. Gut Microbes, https://doi.org/10.1080/19490976.2018.1506667

The mechanisms of efficacy for fecal microbiota# transplantation (FMT) in treating recurrent Clostridioides difficile infection (rCDI) remain poorly defined, with restored gut microbiota-bile acid interactions representing one possible explanation. F... Read More about Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in bile acid-farnesoid X receptor-fibroblast growth factor pathway.

A protein microarray assay for serological determination of antigen-specific antibody responses following Clostridium difficile infection (2018)
Journal Article
Negm, O. H., Hamed, M. R., & Monaghan, T. M. (2018). A protein microarray assay for serological determination of antigen-specific antibody responses following Clostridium difficile infection. Journal of Visualized Experiments, 2018(136), Article e57399. https://doi.org/10.3791/57399

We provide a detailed overview of a novel high-throughput protein microarray assay for the determination of anti-C. difficile antibody levels in human sera and in separate preparations of polyclonal IVIg. The protocol describes the methodological ste... Read More about A protein microarray assay for serological determination of antigen-specific antibody responses following Clostridium difficile infection.

Novel oral targeted therapies in inflammatory bowel disease (2018)
Journal Article
White, J. R., Philips, F., Monaghan, T. M., Fateen, W., Samuel, S., Ghosh, S., & Moran, G. W. (2018). Novel oral targeted therapies in inflammatory bowel disease. Alimentary Pharmacology and Therapeutics, 47(12), 1610-1622. https://doi.org/10.1111/apt.14669

Background: There is a great unmet clinical need for efficacious, tolerable, economical and orally administrated drugs for the treatment of inflammatory bowel disease (IBD). New therapeutic avenues have become possible including the development of me... Read More about Novel oral targeted therapies in inflammatory bowel disease.

Orbital inflammatory complications of Crohn’s disease: a rare case series (2018)
Journal Article
Monaghan, T. M., Albanese, G., Kaye, P., Thomas, J. D., Abercrombie, L., & Moran, G. W. (in press). Orbital inflammatory complications of Crohn’s disease: a rare case series. Clinical Medicine Insights: Gastroenterology, 11, https://doi.org/10.1177/1179552218757512

Orbital inflammatory disease is a rare ophthalmic manifestation of Crohn’s disease. Inflammation is characteristically non-specific, involving one or multiple structures of the orbit. Mechanisms of disease and optimal methods of treatment are poorly... Read More about Orbital inflammatory complications of Crohn’s disease: a rare case series.

High prevalence of subclass-specific binding and neutralizing antibodies against Clostridium difficile toxins in adult cystic fibrosis sera: possible mode of immunoprotection against symptomatic C. difficile infection (2017)
Journal Article
Monaghan, T. M., Negm, O. H., MacKenzie, B., Hamed, M. R., Shone, C. C., Humphreys, D., Acharya, K. R., & Wilcox, M. H. (2017). High prevalence of subclass-specific binding and neutralizing antibodies against Clostridium difficile toxins in adult cystic fibrosis sera: possible mode of immunoprotection against symptomatic C. difficile infection. Clinical and Experimental Gastroenterology, 10, https://doi.org/10.2147/CEG.S133939

Objectives: Despite multiple risk factors and a high rate of colonization for Clostridium difficile, the occurrence of C. difficile infection in patients with cystic fibrosis is rare. The aim of this study was to compare the prevalence of binding C.... Read More about High prevalence of subclass-specific binding and neutralizing antibodies against Clostridium difficile toxins in adult cystic fibrosis sera: possible mode of immunoprotection against symptomatic C. difficile infection.

Protective antibodies against Clostridium difficile are present in intravenous immunoglobulin and are retained in humans following its administration (2017)
Journal Article
Negm, O. H., MacKenzie, B., Hamed, M., Ahmad, O., Shone, C. C., Humphreys, D., Acharya, K. R., Loscher, C. E., Marszalowska, I., Lynch, M., Wilcox, M. H., & Monaghan, T. M. (2017). Protective antibodies against Clostridium difficile are present in intravenous immunoglobulin and are retained in humans following its administration. Clinical and Experimental Immunology, 188(3), 437-443. https://doi.org/10.1111/cei.12946

The prevalence of serum antibodies against Clostridium difficile (CD) toxins A and B in healthy populations have prompted interest in evaluating the therapeutic activity of intravenous immunoglobulin (IVIg) in individuals experiencing severe or recur... Read More about Protective antibodies against Clostridium difficile are present in intravenous immunoglobulin and are retained in humans following its administration.