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Outputs (31)

Changes in IgA-targeted microbiota following fecal transplantation for recurrent Clostridioides difficile infection (2020)
Journal Article
Huus, K. E., Frankowski, M., Pučić-Baković, M., Vučković, F., Lauc, G., Mullish, B. H., Marchesi, J. R., Monaghan, T. M., Kao, D., & Finlay, B. B. (2021). Changes in IgA-targeted microbiota following fecal transplantation for recurrent Clostridioides difficile infection. Gut Microbes, 13(1), 1-12. https://doi.org/10.1080/19490976.2020.1862027

Secretory immunoglobulin A (IgA) interacts with intestinal microbiota and promotes mucosal homeostasis. IgA-bacteria interactions are altered during inflammatory diseases, but how these interactions are shaped by bacterial, host, and environmental fa... Read More about Changes in IgA-targeted microbiota following fecal transplantation for recurrent Clostridioides difficile infection.

Understanding the mechanisms of efficacy of fecal microbiota transplant in treating recurrent Clostridioides difficile infection and beyond: the contribution of gut microbial-derived metabolites (2020)
Journal Article
Martinez-Gili, L., McDonald, J. A., Liu, Z., Kao, D., Allegretti, J. R., Monaghan, T. M., Barker, G. F., Miguéns Blanco, J., Williams, H. R., Holmes, E., Thursz, M. R., Marchesi, J. R., & Mullish, B. H. (2020). Understanding the mechanisms of efficacy of fecal microbiota transplant in treating recurrent Clostridioides difficile infection and beyond: the contribution of gut microbial-derived metabolites. Gut Microbes, 12(1), Article 1810531. https://doi.org/10.1136/gutjnl-2018-317842

Fecal microbiota transplant (FMT) is a highly-effective therapy for recurrent Clostridioides difficile infection (rCDI), and shows promise for certain non-CDI indications. However, at present, its mechanisms of efficacy have remained poorly understo... Read More about Understanding the mechanisms of efficacy of fecal microbiota transplant in treating recurrent Clostridioides difficile infection and beyond: the contribution of gut microbial-derived metabolites.

Metagenomics reveals impact of geography and acute diarrheal disease on the Central Indian human gut microbiome (2020)
Journal Article
Monaghan, T. M., Sloan, T. J., Stockdale, S. R., Blanchard, A. M., Emes, R. D., Wilcox, M., Biswas, R., Nashine, R., Manke, S., Gandhi, J., Jain, P., Bhotmange, S., Ambalkar, S., Satav, A., Draper, L. A., Hill, C., & Kashyap, R. S. (2020). Metagenomics reveals impact of geography and acute diarrheal disease on the Central Indian human gut microbiome. Gut Microbes, 12(1), Article 1752605. https://doi.org/10.1080/19490976.2020.1752605

© 2020, © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. Background: The Central Indian gut microbiome remains grossly understudied. Herein, we sought to investigate the burden of antimicrobial resistance and diarrheal d... Read More about Metagenomics reveals impact of geography and acute diarrheal disease on the Central Indian human gut microbiome.

Metagenomics Reveals Impact of Geography and Acute Diarrhoeal Disease on the Central Indian Human Gut Microbiome (2020)
Journal Article
Monaghan, T. M., Sloan, T. J., Stockdale, S. R., Blanchard, A. M., Emes, R. D., Wilcox, M., Biswas, R., Nashine, R., Manke, S., Gandhi, J., Jain, P., Bhotmange, S., Ambalkar, S., Satav, A., Draper, L. A., Hill, C., & Singh Kashyap, R. (2020). Metagenomics Reveals Impact of Geography and Acute Diarrhoeal Disease on the Central Indian Human Gut Microbiome. Gut Microbes, 12(1), Article 1752605

Background: The Central Indian gut microbiome remains grossly understudied. Herein, we sought to investigate the burden of antimicrobial resistance and diarrhoeal diseases, particularly Clostridioides difficile, in rural-agricultural and urban popula... Read More about Metagenomics Reveals Impact of Geography and Acute Diarrhoeal Disease on the Central Indian Human Gut Microbiome.

Setting the agenda for social science research on the human microbiome (2020)
Journal Article
Greenhough, B., Read, C. J., Lorimer, J., Lezaun, J., McLeod, C., Benezra, A., Bloomfield, S., Brown, T., Clinch, M., D’Acquisto, F., Dumitriu, A., Evans, J., Fawcett, N., Fortané, N., Hall, L. J., Giraldo Herrera, C. E., Hodgetts, T., Johnson, K. V.-A., Kirchhelle, C., Krzywoszynska, A., …Wills, J. (2020). Setting the agenda for social science research on the human microbiome. Palgrave Communications, 6(2020), Article 18

The human microbiome is an important emergent area of cross, multi and transdisciplinary study. The complexity of this topic leads to conflicting narratives and regulatory challenges. It raises questions about the benefits of its commercialisation an... Read More about Setting the agenda for social science research on the human microbiome.

Decreased Complexity of Serum N-glycan Structures Associates with Successful Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection (2019)
Journal Article
Monaghan, T. M., Pučić-Baković, M., Vučković, F., Lee, C., Kao, D., & Human Glycome Project. (2020). Decreased Complexity of Serum N-glycan Structures Associates with Successful Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection. Gastroenterology, 157(6), 1676-1678.e3. https://doi.org/10.1053/j.gastro.2019.08.034

In search of stool donors: a multicenter study of prior knowledge, perceptions, motivators, and deterrents among potential donors for fecal microbiota transplantation (2019)
Journal Article
McSweeney, B., Allegretti, J. R., Fischer, M., Xu, H., Goodman, K. J., Monaghan, T., McLeod, C., Mullish, B. H., Petrof, E. O., Phelps, E. L., Chis, R., Edminson, A., Juby, A., Ennis-Davis, R., Roach, B., Wong, K., & Kao, D. (2020). In search of stool donors: a multicenter study of prior knowledge, perceptions, motivators, and deterrents among potential donors for fecal microbiota transplantation. Gut Microbes, 11(1), 51-62. https://doi.org/10.1080/19490976.2019.1611153

Introduction: Fecal microbiota transplantation (FMT) is a highly effective therapy for recurrent Clostridium difficile infection. Stool donors are essential, but difficult to recruit and retain. We identified factors influencing willingness to donate... Read More about In search of stool donors: a multicenter study of prior knowledge, perceptions, motivators, and deterrents among potential donors for fecal microbiota transplantation.

Lactoferrin-Loaded Alginate Microparticles to Target Clostridioides difficile Infection (2019)
Journal Article
Braim, S., Śpiewakb, K., Brindell, M., Heeg, D., Alexander, C., & Monaghan, T. (2019). Lactoferrin-Loaded Alginate Microparticles to Target Clostridioides difficile Infection. Journal of Pharmaceutical Sciences, 108(7), 2438-2446. https://doi.org/10.1016/j.xphs.2019.02.025

Some forms of bovine lactoferrin (bLf) are effective in delaying Clostridioides difficile growth and preventing toxin production. However, therapeutic use of bLf may be limited by protein stability issues. The objective of this study was to prepare a... Read More about Lactoferrin-Loaded Alginate Microparticles to Target Clostridioides difficile Infection.