Outputs (58)

The Association Between Medication Use in Older Women with Early-Stage Operable Primary Breast Cancer and Decision Regarding Primary Treatment (2023)
Journal Article
Tse, N., Parks, R. M., Holmes, H. M., & Cheung, K. L. (2023). The Association Between Medication Use in Older Women with Early-Stage Operable Primary Breast Cancer and Decision Regarding Primary Treatment. Oncologist, 28(3), e128-e135. https://doi.org/10.1093/oncolo/oyac278

Background Polypharmacy is one factor contributing to increased mortality, hospitalization, and adverse drug reactions in older adults. The aim of this study was to measure the prevalence of polypharmacy in a cohort of older women with early-stage op... Read More about The Association Between Medication Use in Older Women with Early-Stage Operable Primary Breast Cancer and Decision Regarding Primary Treatment.

The impact of age on health utility values for older women with early-stage breast cancer: a systematic review and meta-regression (2022)
Journal Article
Wang, Y., Gavan, S. P., Steinke, D., Cheung, K. L., & Chen, L. C. (2022). The impact of age on health utility values for older women with early-stage breast cancer: a systematic review and meta-regression. Health and Quality of Life Outcomes, 20(1), Article 169. https://doi.org/10.1186/s12955-022-02067-w

Introduction: An increasing number of postmenopausal women are diagnosed with breast cancer at an older age (≥ 70years). There is a lack of synthesised health utility data to support decision-making for managing breast cancer in this older population... Read More about The impact of age on health utility values for older women with early-stage breast cancer: a systematic review and meta-regression.

The impact of the SARS-COV-2 pandemic on the quality of breast cancer care in EUSOMA-certified breast centres (2022)
Journal Article
van Dam, P., Tomatis, M., Ponti, A., Marotti, L., Aristei, C., Biganzoli, L., Cardoso, M. J., Cheung, K. L., Curigliano, G., De Vries, J., Santini, D., Sardanelli, F., Rubio, I. T., Baldini, V., Ballardini, B., Berger, J., Berlière, M., Bonetti, A., Bortul, M., Bussels, B., …Verhoeven, D. (2022). The impact of the SARS-COV-2 pandemic on the quality of breast cancer care in EUSOMA-certified breast centres. European Journal of Cancer, 177, 72-79. https://doi.org/10.1016/j.ejca.2022.09.027

Aims: We analysed the impact of the SARS-CoV-2 pandemic (COVID-19) on the quality of breast cancer care in certified EUSOMA (European Society of Breast Cancer Specialists) breast centres. Materials and methods: The results of the EUSOMA quality indic... Read More about The impact of the SARS-COV-2 pandemic on the quality of breast cancer care in EUSOMA-certified breast centres.

Molecular Biomarker Expression in Window of Opportunity Studies for Oestrogen Receptor Positive Breast Cancer—A Systematic Review of the Literature (2022)
Journal Article
Francis, J. W., Saundh, M., Parks, R. M., & Cheung, K. L. (2022). Molecular Biomarker Expression in Window of Opportunity Studies for Oestrogen Receptor Positive Breast Cancer—A Systematic Review of the Literature. Cancers, 14(20), Article 5027. https://doi.org/10.3390/cancers14205027

Window of opportunity (WoO) trials create the opportunity to demonstrate pharmacodynamic parameters of a drug in vivo and have increasing use in breast cancer research. Most breast cancer tumours are oestrogen receptor-positive (ER+), leading to the... Read More about Molecular Biomarker Expression in Window of Opportunity Studies for Oestrogen Receptor Positive Breast Cancer—A Systematic Review of the Literature.

Updated SIOG COVID-19 working group recommendations on COVID-19 vaccination among older adults with cancer (2022)
Journal Article
Soto-Perez-de-Celis, E., Mislang, A. R., Hernández-Favela, C. G., Russo, C., Colloca, G., Williams, G. R., O'Hanlon, S., Cooper, L., O'Donovan, A., Audisio, R. A., Cheung, K.-L., Gironés-Sarrió, R., Stauder, R., Jaklitsch, M., Cairo, C., Gil, L. A., Alam, M., Sattar, S., Kantilal, K., Loh, K. P., …Battisti, N. M. L. (2022). Updated SIOG COVID-19 working group recommendations on COVID-19 vaccination among older adults with cancer. Journal of Geriatric Oncology, https://doi.org/10.1016/j.jgo.2022.07.005

Improving outcomes for women aged 70 years or above with early breast cancer: research programme including a cluster RCT (2022)
Journal Article
Wyld, L., Reed, M. W., Collins, K., Ward, S., Holmes, G., Morgan, J., Bradburn, M., Walters, S., Burton, M., Lifford, K., Edwards, A., Brain, K., Ring, A., Herbert, E., Robinson, T. G., Martin, C., Chater, T., Pemberton, K., Shrestha, A., Nettleship, A., …Parmeshwar, R. (2022). Improving outcomes for women aged 70 years or above with early breast cancer: research programme including a cluster RCT. Programme Grants for Applied Research, 10(6), 1-114. https://doi.org/10.3310/xzoe2552

Background: In breast cancer management, age-related practice variation is widespread, with older women having lower rates of surgery and chemotherapy than younger women, based on the premise of reduced treatment tolerance and benefit. This may contr... Read More about Improving outcomes for women aged 70 years or above with early breast cancer: research programme including a cluster RCT.

Chemotherapy and gene expression profiling in older early luminal breast cancer patients: An International Society of Geriatric Oncology systematic review (2022)
Journal Article
Battisti, N. M. L., De Glas, N., Soto-Perez-de-Celis, E., Liposits, G., Bringuier, M., Walko, C., Lichtman, S. M., Aapro, M., Cheung, K. L., Biganzoli, L., Ring, A., Portielje, J., Wildiers, H., & Brain, E. (2022). Chemotherapy and gene expression profiling in older early luminal breast cancer patients: An International Society of Geriatric Oncology systematic review. European Journal of Cancer, 172, 158-170. https://doi.org/10.1016/j.ejca.2022.05.039

Background: The benefit of chemotherapy for older patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative early breast cancer (EBC) is a key area of debate. Gene expression profiling (GEP) may identify p... Read More about Chemotherapy and gene expression profiling in older early luminal breast cancer patients: An International Society of Geriatric Oncology systematic review.

Systematic review of the evidence sources applied to cost-effectiveness analyses for older women with primary breast cancer (2022)
Journal Article
Wang, Y., Gavan, S. P., Steinke, D., Cheung, K. L., & Chen, L. C. (2022). Systematic review of the evidence sources applied to cost-effectiveness analyses for older women with primary breast cancer. Cost Effectiveness and Resource Allocation, 20(1), Article 9. https://doi.org/10.1186/s12962-022-00342-7

Objective: To appraise the sources of evidence and methods to estimate input parameter values in decision-analytic model-based cost-effectiveness analyses of treatments for primary breast cancer (PBC) in older patients (≥70years old). Methods: Two el... Read More about Systematic review of the evidence sources applied to cost-effectiveness analyses for older women with primary breast cancer.

Challenges in Geriatric Oncology—A Surgeon’s Perspective (2022)
Journal Article
Parks, R., & Cheung, K. L. (2022). Challenges in Geriatric Oncology—A Surgeon’s Perspective. Current Oncology, 29(2), 659-674. https://doi.org/10.3390/curroncol29020058

As our global population ages, we will see more cancer diagnoses in older adults. Surgery is an important treatment modality for solid tumours, forming the majority of all cancers. However, the management of older adults with cancer can be more compl... Read More about Challenges in Geriatric Oncology—A Surgeon’s Perspective.

An overview of the Nottingham Research Programme on Primary Breast Cancer in Older Women: breast cancer in older women (2021)
Journal Article
Parks, R., & Cheung, K.-L. (2021). An overview of the Nottingham Research Programme on Primary Breast Cancer in Older Women: breast cancer in older women. Liaquat Medical Research Journal, 3(3), 49-52. https://doi.org/10.38106/lmrj.2021.3.3-01

The incidence of breast cancer increases with age. Despite this, most research in this field is aimed at the younger patient. Preliminary studies have shown that older women with breast cancer have distinct biological features compared to their young... Read More about An overview of the Nottingham Research Programme on Primary Breast Cancer in Older Women: breast cancer in older women.