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Outputs (547)

Effect of a 2-week interruption in methotrexate treatment versus continued treatment on COVID-19 booster vaccine immunity in adults with inflammatory conditions (VROOM study): a randomised, open label, superiority trial (2022)
Journal Article
Abhishek, A., Boyton, R. J., Peckham, N., McKnight, Á., Coates, L. C., Bluett, J., Barber, V., Cureton, L., Francis, A., Appelbe, D., Eldridge, L., Julier, P., Valdes, A. M., Brooks, T., Rombach, I., Altmann, D. M., Nguyen-Van-Tam, J. S., Williams, H. C., & Cook, J. A. (2022). Effect of a 2-week interruption in methotrexate treatment versus continued treatment on COVID-19 booster vaccine immunity in adults with inflammatory conditions (VROOM study): a randomised, open label, superiority trial. Lancet Respiratory Medicine, 10(9), 840-850. https://doi.org/10.1016/S2213-2600%2822%2900186-2

Background: Immunosuppressive treatments inhibit vaccine-induced immunity against SARS-CoV-2. We evaluated whether a 2-week interruption of methotrexate treatment immediately after the COVID-19 vaccine booster improved antibody responses against the... Read More about Effect of a 2-week interruption in methotrexate treatment versus continued treatment on COVID-19 booster vaccine immunity in adults with inflammatory conditions (VROOM study): a randomised, open label, superiority trial.

Assessment of Fatigue and Recovery in Sport: Narrative Review (2022)
Journal Article
Bestwick-Stevenson, T., Toone, R., Neupert, E., Edwards, K., & Kluzek, S. (2022). Assessment of Fatigue and Recovery in Sport: Narrative Review. International Journal of Sports Medicine, 43(14), 1151-1162. https://doi.org/10.1055/a-1834-7177

Fatigue is a phenomenon associated with decreases in both physical and cognitive performances and increases in injury occurrence. Competitive athletes are required to complete demanding training programs with high workloads to elicit the physiologica... Read More about Assessment of Fatigue and Recovery in Sport: Narrative Review.

Where are we with developing diagnostic criteria for skin diseases? Mapping the evidence in 2021 (2022)
Journal Article
Luke, J., & Burden-Teh, E. (2022). Where are we with developing diagnostic criteria for skin diseases? Mapping the evidence in 2021. Clinical and Experimental Dermatology, 47(11), 2018-2021. https://doi.org/10.1111/ced.15297

The breadth and scope of dermatological diagnostic criteria is currently unknown. We created a map of diagnostic criteria to provide a panoramic view of past and ongoing research to develop dermatological diagnostic criteria. We analysed studies for... Read More about Where are we with developing diagnostic criteria for skin diseases? Mapping the evidence in 2021.

Neuropsychological evaluation and rehabilitation in multiple sclerosis (NEuRoMS): protocol for a mixed-methods, multicentre feasibility randomised controlled trial (2022)
Journal Article
Topcu, G., Smith, L., Mhizha-Murira, J. R., Goulden, N., Hoare, Z., Drummond, A., Fitzsimmons, D., Evangelou, N., Schmierer, K., Tallantyre, E. C., Leighton, P., Allen-Philbey, K., Stennett, A., Bradley, P., Bale, C., Turton, J., das Nair, R., & On behalf of the NEuRoMS Collective. (2022). Neuropsychological evaluation and rehabilitation in multiple sclerosis (NEuRoMS): protocol for a mixed-methods, multicentre feasibility randomised controlled trial. Pilot and Feasibility Studies, 8(1), Article 123. https://doi.org/10.1186/s40814-022-01073-5

Background: Cognitive problems affect up to 70% of people with multiple sclerosis (MS), which can negatively impact mood, ability to work, and quality of life. Addressing cognitive problems is a top 10 research priority for people with MS. Our ongoin... Read More about Neuropsychological evaluation and rehabilitation in multiple sclerosis (NEuRoMS): protocol for a mixed-methods, multicentre feasibility randomised controlled trial.

A Hybrid Architecture (CO-CONNECT) to Facilitate Rapid Discovery and Access to Data Across the United Kingdom in Response to the COVID-19 Pandemic: Development Study (2022)
Journal Article
Jefferson, E., Cole, C., Mumtaz, S., Cox, S., Giles, T., Adejumo, S., Urwin, E., Lea, D., McDonald, C., Best, J., Masood, E., Milligan, G., Johnston, J., Horban, S., Birced, I., Hall, C., Jackson, A., Collins, C., Rising, S., Dodsley, C., …Quinlan, P. (2022). A Hybrid Architecture (CO-CONNECT) to Facilitate Rapid Discovery and Access to Data Across the United Kingdom in Response to the COVID-19 Pandemic: Development Study. Journal of Medical Internet Research, 24(12), Article e40035. https://doi.org/10.2196/40035

Background:
COVID-19 data have been generated across the United Kingdom as a by-product of clinical care and public health provision, as well as numerous bespoke and repurposed research endeavors. Analysis of these data has underpinned the United Ki... Read More about A Hybrid Architecture (CO-CONNECT) to Facilitate Rapid Discovery and Access to Data Across the United Kingdom in Response to the COVID-19 Pandemic: Development Study.

Prescribing and using vitiligo treatments: lessons from a nested process evaluation within the HI-Light vitiligo randomized controlled trial (2022)
Journal Article
Leighton, P., Chalmers, J. R., Batchelor, J., Rogers, A., Akram, P., Haines, R. H., Meakin, G., White, J., Ravenscroft, J., Sach, T., Santer, M., Whitton, M., Eleftheriadou, V., & Thomas, K. S. (2022). Prescribing and using vitiligo treatments: lessons from a nested process evaluation within the HI-Light vitiligo randomized controlled trial. Clinical and Experimental Dermatology, 47(8), 1480-1489. https://doi.org/10.1111/ced.15193

Background: The HI-Light Trial demonstrated that for active, limited vitiligo, combination treatment with potent topical corticosteroid (TCS) and handheld narrowband ultraviolet B offers a better treatment response than potent TCS alone. However, it... Read More about Prescribing and using vitiligo treatments: lessons from a nested process evaluation within the HI-Light vitiligo randomized controlled trial.

Are polymorphisms affecting serum urate, renal urate handling and alcohol intake associated with co-morbidities in gout cases? A case–control study using data from the UK Biobank (2022)
Journal Article
Sandoval-Plata, G., Morgan, K., & Abhishek, A. (2022). Are polymorphisms affecting serum urate, renal urate handling and alcohol intake associated with co-morbidities in gout cases? A case–control study using data from the UK Biobank. Rheumatology International, 42, 1617-1622. https://doi.org/10.1007/s00296-022-05148-7

Objective: To examine the association between common comorbidities, eGFR and loci involved in the hyperuricaemia-gout transition.

Methods: This study was conducted in people with gout from the UK Biobank. Logistic regression was used to examine th... Read More about Are polymorphisms affecting serum urate, renal urate handling and alcohol intake associated with co-morbidities in gout cases? A case–control study using data from the UK Biobank.

On the definition of dermatological disease. Part 1: conceptual frameworks (2022)
Journal Article
Williams, H. C. (2022). On the definition of dermatological disease. Part 1: conceptual frameworks. Clinical and Experimental Dermatology, 47(10), 1805-1811. https://doi.org/10.1111/ced.15279

Little attention is paid to disease definition in dermatology and how such definitions come about, yet defining a disease is a fundamental step upon which all subsequent clinical management and prognostic judgements depend. Developing diagnostic crit... Read More about On the definition of dermatological disease. Part 1: conceptual frameworks.

Impact of three different phases of UK Covid-19 lockdown restrictions, Covid infections and Covid vaccination status on runners training distance and pace (2022)
Presentation / Conference Contribution
Stocks, J., Bullock, G. S., Feakins, B., Gayer De Mena, L., Tahir, D., Zheng, J., Wang, S., Huang, X., Bestwick-Stevenson, T., Jumbu, N., Simpkins, D., & Kluzek, S. (2022, May). Impact of three different phases of UK Covid-19 lockdown restrictions, Covid infections and Covid vaccination status on runners training distance and pace. Poster presented at BASEM 2022 Conference, Brighton, UK